Rojas Donald C, Camou Suzanne L, Reite Martin L, Rogers Sally J
Department of Psychiatry, University of Colorado Health Sciences Center, Box C268-68 CPH Rm. 2J08, Denver, CO, USA.
J Autism Dev Disord. 2005 Aug;35(4):479-86. doi: 10.1007/s10803-005-5038-7.
Previous research has revealed a lack of planum temporale (PT) asymmetry in adults with autism. This finding is now extended to children and adolescents with the disorder. MRI scans were obtained from 12 children with autism and 12 gender, handedness and age-matched comparison participants. The volume of gray matter in the PT and Heschl's gyrus (HG) in both hemispheres was measured. PT volume was larger in the left hemisphere than in the right in the comparison, but not the autism group. This specifically reflected reduced volume of the left PT in the autism group. There were noted differences in the overall morphological appearance of the right Sylvian fissure in the autism group, but no volumetric difference in the right PT. No differences in HG volumes were observed between the two groups. Lack of PT asymmetry may suggest an early neurodevelopmental disturbance in autism.
先前的研究表明，自闭症成年患者的颞平面（PT）缺乏不对称性。这一发现现在扩展到患有该疾病的儿童和青少年。对12名自闭症儿童以及12名性别、利手和年龄匹配的对照参与者进行了MRI扫描。测量了双侧颞平面和颞横回（HG）的灰质体积。在对照组中，左侧颞平面的体积大于右侧，但自闭症组并非如此。这具体反映出自闭症组左侧颞平面体积减小。注意到自闭症组右侧外侧裂的整体形态外观存在差异，但右侧颞平面没有体积差异。两组之间未观察到颞横回体积的差异。颞平面缺乏不对称性可能表明自闭症存在早期神经发育障碍。
