Huang Xiao-Song, Yang Qi-Dong, Liu Yun-Hai, Liu Zun-Jing
Department of Neurology,Xiangya Hospital, Central South University, Changsha.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2004 Aug;29(4):445-7.
To explore the function of CD62p in cerebral infarction and the relation between the changes of its level and the severity and recovery of cerebral infarction, MPV, PDW and PLT by studying the changes of the levels of plasma CD62p in patients with acute cerebral infarction.
The levels of plasma CD62p were measured by ELISA in 60 patients at 48 hours, 6 - 8 days and 15 days after ischemia, and at the same time, we evaluated neurological function deficiency score and measured MPV, PDW and PLT. The levels of 30 healthy persons mating cerebral infarction group in both sex and ages were measured.
The levels of plasma CD62p in the patients with acute cerebral infarction were obviously higher than the levels of the healthy controls (P < 0.001). The levels of plasma CD62 p in CI group at 48 hours postischemia were higher than the levels at 6 - 8 days and at 15 days with obvious difference (P <0.01). The levels of plasma CD62p in the medium and the severe SSS patients were higher than the levels of the lights (P <0.001). The levels of plasma CD62p were positively correlated with SSS, MPV and PDW (r = 0.61, 0.51, 0.47, P < 0.01), and negatively correlated with PLT (r = -0.32, P < 0.01).
CD62p may participate in acute cerebral infarction and play a crucial role, and the change of its levels correlates with SSS, MPV, PDW and Plt.
通过研究急性脑梗死患者血浆CD62p水平的变化，探讨CD62p在脑梗死中的作用及其水平变化与脑梗死严重程度、恢复情况、平均血小板体积（MPV）、血小板分布宽度（PDW）及血小板计数（PLT）的关系。
采用酶联免疫吸附测定法（ELISA）检测60例患者在缺血后48小时、6 - 8天和15天的血浆CD62p水平，同时评估神经功能缺损评分并检测MPV、PDW和PLT。检测30例年龄和性别匹配的健康对照者的相关指标。
急性脑梗死患者血浆CD62p水平明显高于健康对照组（P < 0.001）。脑梗死（CI）组缺血后48小时血浆CD62p水平高于6 - 8天及15天时，差异有统计学意义（P <0.01）。中度和重度斯堪的纳维亚卒中量表（SSS）患者血浆CD62p水平高于轻度患者（P <0.001）。血浆CD62p水平与SSS、MPV和PDW呈正相关（r = 0.61、0.51、0.47，P < 0.01），与PLT呈负相关（r = -0.32，P < 0.01）。
CD62p可能参与急性脑梗死并起关键作用，其水平变化与SSS、MPV、PDW和PLT相关。
