Huang Li, Guo Huailian, Cheng Min, Zhao Yafeng, Jin Xin
Department of Neurology, People's Hospital, Peking University, Beijing, China.
Eur Neurol. 2007;58(4):224-7. doi: 10.1159/000107944. Epub 2007 Sep 7.
Serum angiogenin (ANG) levels were measured with ELISA in 30 cerebral infarction patients at different time points (within 48 h and on days 3, 7 and 14 after onset of cerebral infarction) and in 20 control subjects. Serum ANG levels in patients were 415.1 +/- 76.8, 410.6 +/- 82.1, 443.6 +/- 91.1 and 395.3 +/- 83.9 ng/ml within 48 h and on days 3, 7 and 14 after cerebral infarction, respectively. Serum ANG level in control group was 334.9 +/- 93.9 ng/ml. Serum ANG levels were significantly higher in patients with cerebral infarction within 48 h and on days 3 and 7 than in the control group (p < 0.05). Serum ANG level decreased on day 14. Serum ANG levels were significantly higher in patients with large infarction than in those with moderate and small infarction at each time point (p < 0.05). Our observations that serum ANG levels increase significantly in patients with cerebral infarction and the increase in ANG levels correlates with the infarct size suggest that ANG might be involved in the pathophysiologic process of ischemic brain damage.
采用酶联免疫吸附测定法（ELISA）检测30例脑梗死患者在不同时间点（脑梗死发病后48小时内以及发病后第3、7和14天）及20例对照者的血清血管生成素（ANG）水平。脑梗死患者在发病后48小时内以及发病后第3、7和14天的血清ANG水平分别为415.1±76.8、410.6±82.1、443.6±91.1和395.3±83.9 ng/ml。对照组血清ANG水平为334.9±93.9 ng/ml。脑梗死患者在发病后48小时内以及发病后第3和7天的血清ANG水平显著高于对照组（p<0.05）。血清ANG水平在第14天下降。在各个时间点，大面积梗死患者的血清ANG水平显著高于中、小面积梗死患者（p<0.05）。我们观察到脑梗死患者血清ANG水平显著升高，且ANG水平的升高与梗死面积相关，这表明ANG可能参与了缺血性脑损伤的病理生理过程。
