撒丁岛的经典卡波西肉瘤：HLA的阳性和阴性关联
Classic Kaposi's sarcoma in Sardinia: HLA positive and negative associations.
作者信息
Masala Maria Vittoria, Carcassi Carlo, Cottoni Francesca, Mulargia Marina, Contu Licinio, Cerimele Decio
机构信息
Department of Dermatology, University of Sassari, and Department of Medical Science, University of Cagliari, Italy.
出版信息
Int J Dermatol. 2005 Sep;44(9):743-5. doi: 10.1111/j.1365-4632.2004.02206.x.
BACKGROUND
The incidence of classic Kaposi's sarcoma (CKS) in northern Sardinia is one of the highest in the world.
METHODS
Sixty-two patients with CKS were typed for class I and class II antigens. All patients had been born and were living in northern Sardinia.
RESULTS
In the Sardinian patients, we observed a positive CKS association with Cw7, DRB11104, DRB11302, DQA10302, and DQB10604, and a negative CKS association with A30, B58, Cw5, DRB11601, and DQB10502.
CONCLUSIONS
The strong positive CKS association with DRB11104 and DQB10604 and negative association with B58 are particularly significant and further support the notion of a genetic predisposition to CKS.
背景
经典型卡波西肉瘤（CKS）在撒丁岛北部的发病率是世界上最高的之一。
方法
对62例CKS患者进行了I类和II类抗原分型。所有患者均出生并生活在撒丁岛北部。
结果
在撒丁岛患者中，我们观察到CKS与Cw7、DRB11104、DRB11302、DQA10302和DQB10604呈正相关，与A30、B58、Cw5、DRB11601和DQB10502呈负相关。
结论
CKS与DRB11104和DQB10604的强正相关以及与B58的负相关尤为显著，进一步支持了CKS存在遗传易感性的观点。
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