Cottoni Francesca, Masala Maria Vittoria, Pattaro Cristian, Pirodda Caterina, Montesu Maria Antonietta, Satta Rosanna, Cerimele Decio, de Marco Roberto
Department of Dermatology, University of Sassari, Italy.
J Am Acad Dermatol. 2006 Dec;55(6):990-5. doi: 10.1016/j.jaad.2006.03.007. Epub 2006 Aug 14.
Studies have demonstrated considerable variations in classic Kaposi sarcoma (CKS) incidence within Europe, with some of the highest incidences found in the Mediterranean area. As a Mediterranean area, northern Sardinia has a high CKS frequency.
In order to determine CKS incidence in people born in and residing in northern Sardinia, a clinical prospective epidemiologic study was carried out between 1977 and 2003 by the Department of Dermatology, University of Sassari. We also evaluated a correlation between malaria prevalence in 1934, estimated on the eight historical sub-areas of the Sassari province, and the standardized morbidity ratio from 1977 to 2003.
A total of 332 patients with CKS were identified. Incidence among the northern Sardinian population > or =40 years of age was 4.06/100,000 persons/year and it was almost stable through the years. The male to female ratio showed a significant decline from 3.6 to 2.5 (P = .03). Females had a statistically decreased risk of developing CKS compared to males (adjusted incidence rate ratio = 0.27; 95% CI: 0.21-0.34), and the risk of developing CKS increased exponentially with age. The prevalence of malaria in each sub-area ranged from 9% to 91%. The standardized morbidity ratio for CKS in the years between 1977 and 2003 ranged from 0.27 to 1.76; the regression coefficient was -0.85 (95% CI: -2.94-1.24), yielding a nonsignificant relationship between the two diseases.
These results were obtained from patients with CKS in northern Sardinia and may not be applicable to other populations.
The northern Sardinian population consistently has a very high incidence of CKS, while in our data, the correlation between malaria and CKS remains open to question.
研究表明，经典型卡波西肉瘤（CKS）在欧洲的发病率存在显著差异，其中地中海地区的发病率最高。作为地中海地区，撒丁岛北部的CKS发病率很高。
为了确定出生并居住在撒丁岛北部的人群中CKS的发病率，萨萨里大学皮肤科于1977年至2003年开展了一项临床前瞻性流行病学研究。我们还评估了1934年在萨萨里省八个历史分区估计的疟疾患病率与1977年至2003年标准化发病率之间的相关性。
共确定了332例CKS患者。撒丁岛北部年龄≥40岁人群的发病率为4.06/10万人口/年，且多年来基本稳定。男女比例从3.6显著下降至2.5（P = 0.03）。与男性相比，女性患CKS的风险在统计学上有所降低（调整发病率比 = 0.27；95%置信区间：0.21 - 0.34），且患CKS的风险随年龄呈指数增长。每个分区的疟疾患病率在9%至91%之间。1977年至2003年期间CKS的标准化发病率在0.27至1.76之间；回归系数为 -0.85（95%置信区间：-2.94 - 1.24），表明两种疾病之间无显著关系。
这些结果来自撒丁岛北部的CKS患者，可能不适用于其他人群。
撒丁岛北部人群的CKS发病率一直很高，而在我们的数据中，疟疾与CKS之间的相关性仍存在疑问。
