超顺磁性纳米颗粒负载的外消旋羧酸盐酶法拆分
Superparamagnetic nanoparticle-supported enzymatic resolution of racemic carboxylates.
作者信息
Gardimalla Hari M R, Mandal Deendayal, Stevens Philip D, Yen Max, Gao Yong
机构信息
Department of Chemistry and Biochemistry, Mailcode 4409, Southern Illinois University, Carbondale, IL 62901-4409, USA.
出版信息
Chem Commun (Camb). 2005 Sep 21(35):4432-4. doi: 10.1039/b504128g. Epub 2005 Aug 11.
DOI:10.1039/b504128g
PMID:16136241
Abstract
Candida rugosa lipase immobilized on maghemite nanoparticles demonstrated high stereoselectivity in kinetic resolution of racemic carboxylates and improved long-term stability over its parent free enzyme, allowing the supported enzyme to be repeatedly used for a series of chiral resolution reactions.
摘要
固定在磁赤铁矿纳米颗粒上的皱褶假丝酵母脂肪酶在消旋羧酸盐的动力学拆分中表现出高立体选择性，并且与其游离的亲本酶相比具有更高的长期稳定性，这使得负载型酶能够重复用于一系列手性拆分反应。
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