Boissier M C, Chiocchia G, Fournier C
INSERM U.283, Hôpital Cochin, Paris, France.
J Rheumatol. 1992 May;19(5):754-7.
We investigated combination treatment with cyclosporine A (CsA) and calcitriol (CT), 2 immunomodulatory agents, in vivo in the adjuvant arthritis (AA) model in rats. Treatment initiated at priming with complete Freund's adjuvant consisted of daily administration of CsA and CT during the prearthritic phase (14 days). CsA given alone delayed the onset of the disease, whereas the severity was either not affected or paradoxically enhanced. Injection of CT alone reduced the severity of arthritis. The association of low doses of CsA (5 mg/kg) and CT (0.2 micrograms/kg) further delayed the onset of AA and abolished the aggravating effect. Our findings suggest that low doses of CsA and CT in association exhibit the additive beneficial effects of either agent alone.
我们在大鼠佐剂性关节炎（AA）模型中对两种免疫调节药物环孢素A（CsA）和骨化三醇（CT）的联合治疗进行了体内研究。在使用完全弗氏佐剂启动免疫时开始治疗，在关节炎前期（14天）每天给予CsA和CT。单独给予CsA可延迟疾病发作，而疾病严重程度要么未受影响，要么反而加重。单独注射CT可减轻关节炎的严重程度。低剂量的CsA（5毫克/千克）和CT（0.2微克/千克）联合使用可进一步延迟AA的发作，并消除加重作用。我们的研究结果表明，低剂量的CsA和CT联合使用表现出单独使用任何一种药物时的相加有益效果。
