Guérin P, Matillon C, Bleau G, Lévy R, Ménézo Y
Ecole nationale vétérinaire (ENV), 1, rue Bourgelat, 69280 Marcy-L'Etoile, France.
Gynecol Obstet Fertil. 2005 Sep;33(9):665-8. doi: 10.1016/j.gyobfe.2005.07.015.
We have used the sperm chromatin structure assay (SCSA) test in order to determine if correlations can be found between sperm DNA fragmentation and spermogram parameters. Only necrospermia and DNA fragmentation index are strongly correlated (P<0.0001). Neither fertilization rates for ICSI and IVF, nor blastocyst formation rates are impaired by a high DFI. However when the critical DFI>30% is reached, the chances of having ongoing pregnancies after blastocyst transfer are reduced by three. Treatments with antioxidants are of limited efficacy even though we obtained 2 deliveries after DFI treatments with such treatments. New strategies in order to improve the pregnancy rates for these peculiar cases of reduced fertility are discussed.
我们采用了精子染色质结构分析（SCSA）试验，以确定精子DNA碎片化与精液分析参数之间是否存在相关性。只有死精症与DNA碎片化指数呈强相关（P<0.0001）。高DNA碎片化指数（DFI）既不影响卵胞浆内单精子注射（ICSI）和体外受精（IVF）的受精率，也不影响囊胚形成率。然而，当临界DFI>30%时，囊胚移植后持续妊娠的几率会降低三分之二。抗氧化剂治疗的疗效有限，尽管我们在使用此类治疗进行DFI治疗后有2例分娩。本文讨论了为提高这些特殊不育病例妊娠率的新策略。
