伴侣组学：体内GroEL功能得以明确。
Chaperomics: in vivo GroEL function defined.
作者信息
Ellis R John
机构信息
Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK.
出版信息
Curr Biol. 2005 Sep 6;15(17):R661-3. doi: 10.1016/j.cub.2005.08.025.
PMID:16139196
Abstract
A recent proteome analysis of protein folding inside cells of Escherichia coli predicts that only 84 of the approximately 2400 cytosolic proteins expressed in minimal media depend absolutely on the GroEL/GroES chaperone system to avoid aggregation. These proteins are enriched in alpha/beta domains and 13 are essential for growth.
摘要
最近一项针对大肠杆菌细胞内蛋白质折叠的蛋白质组分析预测，在基本培养基中表达的约2400种胞质蛋白中，只有84种绝对依赖GroEL/GroES伴侣系统来避免聚集。这些蛋白质富含α/β结构域，其中13种对生长至关重要。
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