恶性疟原虫：莽草酸类似物与抗疟药物的相互作用
Plasmodium falciparum: interaction of shikimate analogues with antimalarial drugs.
作者信息
McRobert Louisa, Jiang Shende, Stead Andrew, McConkey Glenn A
机构信息
School of Biology, University of Leeds, Leeds LS2 9JT, UK.
出版信息
Exp Parasitol. 2005 Nov;111(3):178-81. doi: 10.1016/j.exppara.2005.07.002. Epub 2005 Sep 6.
The shikimate pathway for aromatic biosynthesis presents a target for antimalarial drug development as this pathway is absent from animals. This study extends previous work on inhibitors of the shikimate pathway, by examining their interaction with the antimalarial drugs pyrimethamine and atovaquone. Combinations of atovaquone with several shikimate analogues exhibited synergistic effects. These findings highlight potential use of shikimate pathway inhibitors in combination therapy.
用于芳香族生物合成的莽草酸途径是抗疟药物开发的一个靶点，因为动物体内不存在该途径。本研究通过检测莽草酸途径抑制剂与抗疟药物乙胺嘧啶和阿托伐醌的相互作用，扩展了之前关于莽草酸途径抑制剂的研究工作。阿托伐醌与几种莽草酸类似物的组合表现出协同效应。这些发现凸显了莽草酸途径抑制剂在联合治疗中的潜在用途。
Zotero 插件