Canfield C J, Pudney M, Gutteridge W E
Pharmaceutical Systems Incorporated, Gaithersburg, Maryland 20879, USA.
Exp Parasitol. 1995 May;80(3):373-81. doi: 10.1006/expr.1995.1049.
A series of Plasmodium falciparum in vitro drug sensitivity studies were conducted in order to evaluate atovaquone in combination with other antimalarial drugs and thus to identify a potential partner for a fixed combination. The derived isobolograms indicated that drug interactions ranged from antagonism through addition to synergy. Of particular note were the quinolines and artemisinin analogues, which were all antagonistic, and the biguanides and tetracycline, which showed synergy. Proguanil emerged as the most promising of the current antimalarials as a partner for atovaquone in a fixed combination, with tetracycline as back-up.
为了评估阿托伐醌与其他抗疟药物联合使用的效果，从而确定一种潜在的固定复方组合搭档，开展了一系列恶性疟原虫体外药敏研究。所得的等效线图表明，药物相互作用范围从拮抗到相加再到协同。特别值得注意的是喹啉类和青蒿素类似物，它们均表现为拮抗作用，而双胍类和四环素则表现出协同作用。在目前的抗疟药物中，氯胍作为阿托伐醌固定复方组合的搭档最具前景，四环素作为备选。
