用于诊断性腺功能减退的筛查问卷比较
Comparison of screening questionnaires for the diagnosis of hypogonadism.
作者信息
Morley John E, Perry H M, Kevorkian R T, Patrick P
机构信息
Division of Geriatric Medicine, Saint Louis University School of Medicine, 1402 S. Grand Blvd., M238, St. Louis, MO 63104, USA.
出版信息
Maturitas. 2006 Mar 20;53(4):424-9. doi: 10.1016/j.maturitas.2005.07.004. Epub 2005 Sep 2.
Three questionnaires, the St. Louis University Androgen Deficiency in Aging Male (ADAM), the Aging Male Survey (AMS) and the Massachusetts Male Aging Study (MMAS), have been developed as potential screening tools for hypogonadism in older males. We compared these questionnaires in 148 males aged 23-80 years using bioavailable testosterone as the "biochemical gold standard" for diagnosis of hypogonadism. The sensitivity for the ADAM was 97%, for the AMS 83% and the MMAS 60%. Specificity was 30% for the ADAM, 59% for the MMAS and 39% for AMS. Both bioavailable testosterone and the calculated free testosterone correlated significantly with a number of the individual questions. Total testosterone correlated poorly with most of the questions. In conclusion, the ADAM and AMS may be useful screening tools for hypogonadism across the adult lifespan, but both are relatively nonspecific.
已经开发出三种调查问卷，即圣路易斯大学男性衰老雄激素缺乏症（ADAM）、男性衰老调查（AMS）和马萨诸塞州男性衰老研究（MMAS），作为老年男性性腺功能减退的潜在筛查工具。我们以生物可利用睾酮作为诊断性腺功能减退的“生化金标准”，对148名年龄在23至80岁之间的男性进行了这些调查问卷的比较。ADAM的敏感性为97%，AMS为83%，MMAS为60%。ADAM的特异性为30%，MMAS为59%，AMS为39%。生物可利用睾酮和计算得出的游离睾酮均与许多单个问题显著相关。总睾酮与大多数问题的相关性较差。总之，ADAM和AMS可能是整个成年期性腺功能减退的有用筛查工具，但两者都相对缺乏特异性。
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