el Nahas A M
Sheffield Kidney Institute, United Kingdom.
Kidney Int Suppl. 1992 May;36:S15-20.
Progress has been made over the last decade in our understanding of the pathophysiology of progressive chronic renal failure (CRF) and the underlying glomerular sclerosis. Although these advances have been made in experimental animals and have so far had little impact on the management of CRF in humans, they nevertheless identify pathways through which glomerular sclerosis takes place. They also identify the cells involved in this process and the role of cytokines/growth-promoting peptides in the communication between these cells. It is the purpose of this review to detail the contribution of cytokines to glomerular scarring.
在过去十年中，我们对进行性慢性肾衰竭（CRF）的病理生理学及潜在的肾小球硬化的理解取得了进展。尽管这些进展是在实验动物中取得的，且迄今为止对人类CRF的治疗影响甚微，但它们确定了肾小球硬化发生的途径。它们还确定了参与这一过程的细胞以及细胞因子/生长促进肽在这些细胞间通讯中的作用。本综述的目的是详细阐述细胞因子对肾小球瘢痕形成的作用。
