Pillay Thillagavathie, Zhang Hua-Tang, Drijfhout Jan W, Robinson Nicola, Brown Helen, Khan Munira, Moodley Jagadesa, Adhikari Miriam, Pfafferott Katja, Feeney Margaret E, St John Anne, Holmes Edward C, Coovadia Hoosen M, Klenerman Paul, Goulder Philip J R, Phillips Rodney E
The Peter Medawar Building for Pathogen Research and Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom.
J Virol. 2005 Sep;79(18):12100-5. doi: 10.1128/JVI.79.18.12100-12105.2005.
The role of cytotoxic T-lymphocyte (CTL) escape in rapidly progressive infant human immunodeficiency virus type 1 (HIV-1) infection is undefined. The data presented here demonstrate that infant HIV-1-specific CTL can select for viral escape variants very early in life. These variants, furthermore, may be selected specifically in the infant, despite the same CTL specificity being present in the mother. Additionally, pediatric CTL activity may be compromised both by the transmission of maternal escape variants and by mother-to-child transmission of escape variants that originally arose in the father. The unique acquisition of these CTL escape forms may help to explain the severe nature of some pediatric HIV infections.
细胞毒性T淋巴细胞（CTL）逃逸在快速进展的婴儿1型人类免疫缺陷病毒（HIV-1）感染中的作用尚不清楚。此处呈现的数据表明，婴儿HIV-1特异性CTL可在生命早期就选择出病毒逃逸变异株。此外，尽管母亲体内存在相同的CTL特异性，但这些变异株可能在婴儿体内被特异性选择。另外，母体逃逸变异株的传播以及最初在父亲体内出现的逃逸变异株的母婴传播，都可能损害儿童的CTL活性。这些CTL逃逸形式的独特获得情况可能有助于解释某些儿童HIV感染的严重性质。
