围产期缺氧缺血损伤中的营养与免疫。
Nutrition and Immunity in Perinatal Hypoxic-Ischemic Injury.
机构信息
Department of Neonatology, University Hospitals Leicester NHS Trust, Leicester LE1 5WW, UK.
East Midlands Deanery, Health Education England, Leicester LE3 5DR, UK.
出版信息
Nutrients. 2022 Jul 1;14(13):2747. doi: 10.3390/nu14132747.
Perinatal hypoxia ischaemia (PHI), acute and chronic, may be associated with considerable adverse outcomes in the foetus and neonate. The molecular and cellular mechanisms of injury and repair associated with PHI in the perinate are not completely understood. Increasing evidence is mounting for the role of nutrients and bioactive food components in immune development, function and repair in PHI. In this review, we explore current concepts around the neonatal immune response to PHI with a specific emphasis on the impact of nutrition in the mother, foetus and neonate.
围产期缺氧缺血（PHI），无论是急性还是慢性，都可能与胎儿和新生儿的严重不良后果有关。与围产期 PHI 相关的损伤和修复的分子和细胞机制尚未完全清楚。越来越多的证据表明，营养物质和生物活性食物成分在 PHI 中的免疫发育、功能和修复中起作用。在这篇综述中，我们探讨了目前关于新生儿对 PHI 的免疫反应的概念，特别强调了营养在母亲、胎儿和新生儿中的影响。
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