Honda S, Matsuo M
Tokyo Metropolitan Institute of Gerontology, Japan.
Mech Ageing Dev. 1992 May;63(3):235-46. doi: 10.1016/0047-6374(92)90002-u.
The effects of higher concentrations of atmospheric oxygen on the lifespans of wild type and a temperature-sensitive zyg-9(b244) mutant of the nematode Caenorhabditis elegans were examined. Their mean and maximum lifespans decreased with increasing oxygen concentration. The mean and maximum lifespans of the wild type under 60, 75, and 90% oxygen shrunk by 17 and 10, 31 and 31, and 40 and 41%, respectively, as compared with those under 21% oxygen (normal air). The mean and maximum lifespan of the zyg-9(b244) mutant under 60 and 90% oxygen shrunk by 18 and 22%, and 38 and 39%, respectively, as compared with those under 21% oxygen. The Gompertz analysis of the survival data of the wild type revealed that the exponential Gompertz component, the rate of acceleration of mortality, increased with increasing oxygen concentration: i.e. the ageing was accelerated under higher concentrations of oxygen. Oxygen acts as a lifespan determinant of the nematode. When the animals were exposed to a high concentration of oxygen at the early phase of lifespan, the oxygen-induced lifespan shortening was not observed. This means that oxygen-induced damage leading to lifespan shortening is repaired under 21% oxygen and that the oxygen-induced lifespan shortening does not result from any alteration in development and/or mutation.
研究了较高浓度的大气氧对线虫秀丽隐杆线虫野生型和温度敏感型zyg - 9(b244)突变体寿命的影响。它们的平均寿命和最大寿命随着氧浓度的增加而降低。与21%氧气（正常空气）条件下相比，野生型在60%、75%和90%氧气条件下的平均寿命和最大寿命分别缩短了17%和10%、31%和31%、40%和41%。与21%氧气条件下相比，zyg - 9(b244)突变体在60%和90%氧气条件下的平均寿命和最大寿命分别缩短了18%和22%、38%和39%。对野生型存活数据的Gompertz分析表明，指数Gompertz成分，即死亡率加速率，随着氧浓度的增加而增加：也就是说，在较高浓度的氧气条件下衰老加速。氧气是线虫寿命的决定因素。当动物在寿命早期暴露于高浓度氧气时，未观察到氧气诱导的寿命缩短。这意味着在21%氧气条件下，导致寿命缩短的氧气诱导损伤得到修复，并且氧气诱导的寿命缩短不是由发育改变和/或突变引起的。
