Pérez-Rey D, Maojo V, García-Remesal M, Alonso-Calvo R, Billhardt H, Martin-Sánchez F, Sousa A
Biomedical Informatics Group, Artificial Intelligence Laboratory, School of Computer Science, Universidad Politecnica de Madrid, 28660 Boadilla del Monte, Spain.
Comput Biol Med. 2006 Jul-Aug;36(7-8):712-30. doi: 10.1016/j.compbiomed.2005.02.004. Epub 2005 Sep 6.
ONTOFUSION is an ontology-based system designed for biomedical database integration. It is based on two processes: mapping and unification. Mapping is a semi-automated process that uses ontologies to link a database schema with a conceptual framework-named virtual schema. There are three methodologies for creating virtual schemas, according to the origin of the domain ontology used: (1) top-down--e.g. using an existing ontology, such as the UMLS or Gene Ontology--, (2) bottom-up--building a new domain ontology-- and (3) a hybrid combination. Unification is an automated process for integrating ontologies and hence the database to which they are linked. Using these methods, we employed ONTOFUSION to integrate a large number of public genomic and clinical databases, as well as biomedical ontologies.
ONTOFUSION是一个基于本体的系统，旨在用于生物医学数据库集成。它基于两个过程：映射和统一。映射是一个半自动过程，使用本体将数据库模式与一个名为虚拟模式的概念框架相链接。根据所使用的领域本体的来源，有三种创建虚拟模式的方法：(1)自上而下——例如使用现有的本体，如统一医学语言系统（UMLS）或基因本体——(2)自下而上——构建一个新的领域本体——以及(3)混合组合。统一是一个用于集成本体以及与之链接的数据库的自动化过程。使用这些方法，我们采用ONTOFUSION来集成大量公共基因组和临床数据库以及生物医学本体。
