Freeman Hugh J
Department of Medicine (Gastroenterology), University of British Columbia, Vancouver, British Columbia, Canada.
J Clin Gastroenterol. 2005 Oct;39(9):774-7. doi: 10.1097/01.mcg.0000177243.51967.ca.
Crohn's disease is a heterogeneous disorder that involves different sites along the length of the gastrointestinal tract. It is usually characterized by a high rate of strictures and penetrating complications. The present study used the modified Vienna classification schema to explore the specific role of age at diagnosis on both disease location and disease behavior. There were 1,015 consecutively evaluated patients, including 449 males and 566 females. Disease was most often localized in the ileocolon and could be most often classified as complex disease (ie, in >70%) with strictures or penetrating complications. For both males and females, with increasing age at diagnosis, disease became less extensive, more often localized in the colon alone, and disease behavior could be characterized as more complex, especially with penetrating disease complications. These results demonstrate the phenomenon of age dependence in the phenotypic clinical expression of Crohn's disease.
克罗恩病是一种异质性疾病，累及胃肠道全长的不同部位。其通常的特征是狭窄和穿透性并发症的发生率较高。本研究使用改良的维也纳分类方案，探讨诊断时年龄对疾病部位和疾病行为的具体作用。共有1015例连续评估的患者，其中男性449例，女性566例。疾病最常定位于回结肠，最常被归类为伴有狭窄或穿透性并发症的复杂性疾病（即>70%）。对于男性和女性而言，随着诊断时年龄的增加，疾病范围变小，更常仅局限于结肠，且疾病行为可被描述为更复杂，尤其是伴有穿透性疾病并发症时。这些结果证明了克罗恩病表型临床表达中的年龄依赖性现象。
