Aljebreen Abdulrahman M, Alharbi Othman R, Azzam Nahla A, Almalki Ahmed S, Alswat Khalid A, Almadi Majid A
Gastroenterology Division, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia, .
Saudi J Gastroenterol. 2014 May-Jun;20(3):162-9. doi: 10.4103/1319-3767.132993.
BACKGROUND/AIMS: Despite the remarkable increase in the incidence of Crohn's disease among Saudis in recent years, data about Crohn's disease in Saudi Arabia are scarce. The aim of this study was to determine the clinical epidemiology and phenotypic characteristics of Crohn's disease in the central region of Saudi Arabia.
A data registry, Inflammatory Bowel Disease Information System (IBDIS), was used to register Crohn's disease patients who presented to the gastroenterology clinics in four tertiary care centers in Riyadh, Saudi Arabia between September 2009 and February 2013. Patients' characteristics, disease location, behavior, age at diagnosis according to the Montreal classification, course of the disease, and extraintestinal manifestation were recorded.
Among 497 patients with Crohn's disease, 59% were males with a mean age at diagnosis of 25 years [95% Confidence Interval (CI): 24-26, range 5-75 years]. The mean duration from the time of complaint to the day of the diagnosis was 11 months, and the mean duration of the disease from diagnosis to the day of entry to the registry was 40 months. Seventy-seven percent of our patients were aged 17-40 years at diagnosis, 16.8% were ≤16 years of age, and 6.6% were >40 years of age. According to the Montreal classification of disease location, 48.8% of patients had ileocolonic involvement, 43.5% had limited disease to the terminal ileum or cecum, 7.7% had isolated colonic involvement, and 16% had an upper gastrointestinal involvement. Forty-two percent of our patients had a non-stricturing, non-penetrating behavior, while 32.8% had stricturing disease and 25.4% had penetrating disease.
Crohn's disease is frequently encountered in Saudi Arabia. The majority of patients are young people with a predilection for males, while its behavior resembled that of western societies in terms of age of onset, location, and behavior.
背景/目的：尽管近年来沙特人中克罗恩病的发病率显著上升，但沙特阿拉伯关于克罗恩病的数据却很稀少。本研究的目的是确定沙特阿拉伯中部地区克罗恩病的临床流行病学和表型特征。
使用一个数据登记系统，即炎症性肠病信息系统（IBDIS），来登记2009年9月至2013年2月期间在沙特阿拉伯利雅得的四个三级医疗中心的胃肠病诊所就诊的克罗恩病患者。记录患者的特征、疾病部位、行为、根据蒙特利尔分类法的诊断年龄、疾病进程以及肠外表现。
在497例克罗恩病患者中，59%为男性，诊断时的平均年龄为25岁[95%置信区间（CI）：24 - 26，范围5 - 75岁]。从出现症状到诊断之日的平均时长为11个月，从诊断到进入登记系统之日的疾病平均病程为40个月。77%的患者诊断时年龄在17 - 40岁之间，16.8%的患者年龄≤16岁，6.6%的患者年龄>40岁。根据疾病部位的蒙特利尔分类法，48.8%的患者有回结肠受累，43.5%的患者疾病局限于末端回肠或盲肠，7.7%的患者有孤立性结肠受累，16%的患者有上消化道受累。42%的患者有非狭窄、非穿透性行为，而32.8%的患者有狭窄性疾病，25.4%的患者有穿透性疾病。
克罗恩病在沙特阿拉伯较为常见。大多数患者为年轻人，男性居多，其发病年龄、部位和行为方面的表现与西方社会相似。
