Guan Peng, Tajimi Morihiro, Uehara Ritei, Watanabe Makoto, Oki Izumi, Ojima Toshiyuki, Nakamura Yosikazu
Department of Public Health, Jichi Medical School, 3311-1 Yakushiji, Minamikawachi, Tochigi 329-0498, Japan.
Chemosphere. 2006 Feb;62(7):1161-6. doi: 10.1016/j.chemosphere.2005.06.059. Epub 2005 Sep 15.
Exposure to dioxins has raised much public concern recently. We determined the congeners' distribution of polychlorinated-dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (dl-PCBs) in the breast milk samples collected in Tokyo, Japan. Breast milk was taken from 240 mothers, 30 days after delivery in 1999 and 2000 in Tokyo, Japan. The actual concentration and TEQ concentration of PCDDs (14 congeners), PCDFs (15 congeners), and dl-PCBs (12 congeners), and each congener's contribution to the total TEQ level were calculated. Among all the samples, PCDDs accounted for 34.8%, PCDFs accounted for 23.5%, dl-PCBs accounted for 41.7%, which was also similar in the breast milk from the primiparae and secundiparae. The main contributors to the total TEQ with increasing percentages were 2,3,4,7,8-PeCDF, 1,2,3,7,8-PeCDD and 3,3',4,4',5-PCB (#126), and they accounted for more than 65% of the total TEQ. Detailed congener analysis in breast milk samples is effective to understand dioxin sources.
近期，二噁英暴露引发了公众的广泛关注。我们测定了在日本东京采集的母乳样本中多氯代二苯并 - 对 - 二噁英（PCDDs）、多氯代二苯并呋喃（PCDFs）和类二噁英多氯联苯（dl - PCBs）同系物的分布情况。母乳取自1999年和2000年在日本东京产后30天的240位母亲。计算了PCDDs（14种同系物）、PCDFs（15种同系物）和dl - PCBs（12种同系物）的实际浓度和毒性当量浓度，以及每种同系物对总毒性当量水平的贡献。在所有样本中，PCDDs占34.8%，PCDFs占23.5%，dl - PCBs占41.7%，初产妇和经产妇的母乳中情况也相似。对总毒性当量贡献百分比不断增加的主要同系物为2,3,4,7,8 - 五氯代二苯并呋喃、1,2,3,7,8 - 五氯代二苯并二噁英和3,3',
