Panosetti E
Clinic for Otorhinolaryngology, Kantonsspital, Luzern, Switzerland.
ORL J Otorhinolaryngol Relat Spec. 1992;54(2):95-9. doi: 10.1159/000276271.
In this randomized trial, 100 patients received ceftriaxone or amoxicillin-clavulanic acid in phlegmonous or abscess-forming ENT infections. Clinical and bacteriological results confirm that both antibiotics are equally effective, the advantage of ceftriaxone being one administration a day. Drainage surgery is necessary when an abscess has already formed. In 4 cases (ceftriaxone: 3; amoxicillin-clavulanic acid: 1), no positive response could be observed. Systemic and local tolerance was, as a general rule, excellent, and side effects were reported in 3 cases of the ceftriaxone group and in 3 cases of the amoxicillin-clavulanic acid group.
在这项随机试验中，100例患有蜂窝织炎或脓肿形成的耳鼻喉感染患者接受了头孢曲松或阿莫西林-克拉维酸治疗。临床和细菌学结果证实，两种抗生素同样有效，头孢曲松的优势在于每日给药一次。脓肿形成时需要进行引流手术。4例患者（头孢曲松组：3例；阿莫西林-克拉维酸组：1例）未观察到阳性反应。一般来说，全身和局部耐受性良好，头孢曲松组有3例报告了副作用，阿莫西林-克拉维酸组也有3例报告了副作用。
