Moodley M, Garib R
Department of Gynaecology and Oncology, Nelson R. Mandela School of Medicine, Durban, South Africa.
J Obstet Gynaecol. 2004 Nov;24(8):903-6. doi: 10.1080/01443610400018908.
Human immunodeficiency virus (HIV) infection is a risk factor for both human papillomavirus infection (HPV) and cervical squamous intraepithelial lesions (SIL). This study was undertaken to determine the prevalence of underlying SIL among women with a cytological diagnosis of HPV infection alone. Of 160 women, the overall prevalence of HIV infection and SIL was 41.9% and 36.9%, respectively. Biopsy which confirmed SIL of any grade was demonstrated in 49.3% and 28% of HIV-infected and HIV-non-infected women. However, for individual grade of SIL, there was no statistical significant difference among the HIV-infected and HIV-non-infected groups. Although the finding of a cytological diagnosis of HPV among HIV-non-infected women is usually managed conservatively, the finding of a high rate of underlying SIL among HIV-infected women may argue against such a conservative approach.
人类免疫缺陷病毒（HIV）感染是人类乳头瘤病毒感染（HPV）和宫颈鳞状上皮内病变（SIL）的一个风险因素。本研究旨在确定仅经细胞学诊断为HPV感染的女性中潜在SIL的患病率。在160名女性中，HIV感染和SIL的总体患病率分别为41.9%和36.9%。在49.3%的HIV感染女性和28%的未感染HIV女性中，活检证实存在任何级别的SIL。然而，对于SIL的各个级别，HIV感染组和未感染HIV组之间没有统计学上的显著差异。虽然在未感染HIV的女性中，细胞学诊断为HPV通常采用保守治疗，但在感染HIV的女性中发现潜在SIL的高发生率可能不支持这种保守方法。
