三胞胎中的宫内烟草烟雾暴露与透明膜病

Intrauterine tobacco smoke exposure and hyaline membrane disease amongst triplets.

作者信息

Salihu H M, McCainey T N, Aliyu M H, Williams A T, Dimmitt R A, Alexander G R

机构信息

Department of Maternal and Child Health, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.

出版信息

J Obstet Gynaecol. 2005 Jan;25(1):23-7. doi: 10.1080/01443610400022496.

DOI:10.1080/01443610400022496

PMID:16147688

Abstract

We assessed the association between prenatal smoking and respiratory distress syndrome (RDS) among triplets using a population-based retrospective cohort of 12,169 triplet live births in the United States between 1995 and 1997. Analysis was conducted using the generalised estimating equation framework to adjust for intra-cluster correlations. A total of 938 cases of RDS were reported comprising 35 among smoking (7.2%) and 903 among non-smoking gravidas (7.7%). The likelihood of RDS was comparable in both smoking categories [adjusted odds ratio (OR) = 0.93; 95% confidence interval (CI) = 0.65-1.32]. The risk for RDS due to smoking diminished with declining birth weight albeit non-significantly: low birth weight (OR = 0.99; 95% CI = 0.40-2.42), very low birth weight (OR = 0.85; 95% CI = 0.39-1.86), and extremely low birth weight (OR = 0.69; 95% CI = 0.30-1.58). In conclusion, among triplet neonates, smoking during pregnancy was not associated with respiratory distress syndrome.

摘要

我们利用1995年至1997年美国12169例三胞胎活产的基于人群的回顾性队列，评估了三胞胎产前吸烟与呼吸窘迫综合征（RDS）之间的关联。分析采用广义估计方程框架进行，以调整集群内相关性。共报告了938例RDS病例，其中吸烟孕妇中有35例（7.2%），非吸烟孕妇中有903例（7.7%）。两种吸烟类别中RDS的可能性相当[调整后的优势比（OR）=0.93；95%置信区间（CI）=0.65 - 1.32]。尽管不显著，但随着出生体重下降，吸烟导致RDS的风险降低：低出生体重（OR = 0.99；95% CI = 0.40 - 2.42）、极低出生体重（OR = 0.85；95% CI = 0.39 - 1.86）和极极低出生体重（OR = 0.69；95% CI = 0.30 - 1.58）。总之，在三胞胎新生儿中，孕期吸烟与呼吸窘迫综合征无关。