Sulaberidze G T, Rachvelishvili B K, Gelbakhiani G P, Zedania Z S, Berchashvili A E
Georgian Med News. 2005 Jul-Aug(124-125):50-3.
The aim of the work was to study the indicators of pH and kinematic viscosity of the contents of the gall-bladder at receiving B-portion and their changes after a 7-hour period according to the biliary sediment of patients and to establish their link to the infection. Total 31 patients aged 25-55 with biliary sediment in lumens of their gall-bladders (a general group) and 5 healthy patients (a control group) were studied by us. In all cases the markers of the virus of Hepatitis B in blood serum were determined and ultrasonic examination of gall-bladder was carried out by us prior to the duodenal intubation. B-portion was subjected to bacteriological research for aerobes and anaerobs, and pH and kinematic viscosity (eta=mm(2)/sec) were determined. The patients from the control as well as from the general group after a 7-hour period were redetermined pH and Kinematic viscosity of B-portion. Kinematic viscosity was determined with a capillary viscosimeter, and pH was fixed by a method of potentiometer. Statistical treatment was undertaken by the method of ANOLA p<0,05. During the duodenal intubation the mean value of pH within the control group was fixed at 6.74, and the mean value of the kinematic viscosity was 1.34, and after a 7-hour period the same indicators constituted 6.87 and 1.35 mm(2)/sec, respectively. The same indicators within the general group during duodenal intubation were the following: 7.26 and 1.99 mm(2)/sec, and after a 7-hour period the same indicators were 7.78 and 2.19 mm(2)/sec, respectively. There was a significant statistical difference between the mean values of pH and kinematic viscosity of the contents of gall-bladder of the patients from the control and general groups. During a 7-hour period, there was also a significant statistical difference between the changes of the same indicators. The difference was even greater in case of infection. Following the above-mentioned we can conclude that in case of sediment in the lumen of gall-bladder, inclination of pH to alkalinity and increase in kinematic viscosity of the contents is one of the most important criteria of lithogenicity of gall-bladder contents, and one of the reasons for such changes is chronic infection of a gall-bladder.
该研究的目的是根据患者的胆汁沉积物，研究在获取B部分时胆囊内容物的pH值和运动粘度指标，以及7小时后的变化情况，并确定它们与感染的关系。我们对31名年龄在25至55岁、胆囊腔内有胆汁沉积物的患者（一般组）和5名健康患者（对照组）进行了研究。在所有病例中，在十二指肠插管前，我们测定了血清中乙肝病毒标志物，并对胆囊进行了超声检查。对B部分进行了需氧菌和厌氧菌的细菌学研究，并测定了pH值和运动粘度（η=mm²/sec）。对照组和一般组的患者在7小时后重新测定了B部分的pH值和运动粘度。运动粘度用毛细管粘度计测定，pH值用电位计法测定。采用ANOLA方法进行统计学处理，p<0.05。在十二指肠插管期间，对照组内pH值的平均值为6.74，运动粘度的平均值为1.34，7小时后，相同指标分别为6.87和1.35mm²/sec。一般组在十二指肠插管期间的相同指标如下：7.26和1.99mm²/sec，7小时后，相同指标分别为7.78和2.19mm²/sec。对照组和一般组患者胆囊内容物的pH值和运动粘度平均值之间存在显著的统计学差异。在7小时期间，相同指标的变化之间也存在显著的统计学差异。在感染情况下差异更大。综上所述，我们可以得出结论，在胆囊腔内有沉积物的情况下，胆囊内容物的pH值向碱性倾斜以及运动粘度增加是胆囊内容物致石性的最重要标准之一，而这种变化的原因之一是胆囊的慢性感染。
