Kanngiesser Hartmut E, Kniestedt Christoph, Robert Yves C A
Research and Development, Swiss Microtechnology AG, Port, Switzerland.
J Glaucoma. 2005 Oct;14(5):344-50. doi: 10.1097/01.ijg.0000176936.16015.4e.
With tonometers currently in use intraocular pressure is indirectly determined by measuring a physical quantity related to a specified deformation of the cornea. We present a new principle of direct, continuous, and transcorneal intraocular pressure measurement, describe its theoretical foundation, and evaluate its application on the basis of an in vitro model.
On a living human eye an optimized pressure-sensitive contact surface was determined by performing pressure measurements with differently shaped tonometer heads. Based on these results and on the theoretical model, a Dynamic Contour Tonometer was constructed and validated on eye bank bulbi against a manometric reference pressure.
A concave contact surface with a radius of curvature of 10.5 mm creates a distribution of forces between the central contour matching area of the tip and the cornea that equals the forces generated by the internal pressure of the eye. A sensor integrated into the surface having the same contour measures the intraocular pressure closely to the manometric reference pressure in human cadaver eyes. The accuracy of the tonometer appears to be unaffected by variations in corneal properties.
Dynamic Contour Tonometry eliminates most of the systematic errors arising from individual changes of corneal properties that adversely influence all types of applanation tonometers. The advantage of measuring the true pressure in combination with the capability of registering dynamic pressure fluctuations discloses new tonometric opportunities to diagnose and classify different types of glaucoma.
目前使用的眼压计是通过测量与角膜特定变形相关的物理量来间接测定眼压。我们提出一种直接、连续且经角膜测量眼压的新原理,描述其理论基础,并基于体外模型评估其应用。
在人眼活体上,通过使用不同形状的眼压计探头进行压力测量,确定了一个优化的压敏接触面。基于这些结果和理论模型,构建了动态轮廓眼压计,并在眼库眼球上相对于压力计参考压力进行了验证。
曲率半径为10.5毫米的凹形接触面在探头的中央轮廓匹配区域与角膜之间产生的力分布,等同于眼内压产生的力。集成在具有相同轮廓表面的传感器,在人尸体眼中测量的眼压与压力计参考压力非常接近。眼压计的准确性似乎不受角膜特性变化的影响。
动态轮廓眼压测量法消除了因角膜特性个体差异而产生的大部分系统误差,这些误差对所有类型的压平眼压计都有不利影响。测量真实压力的优势与记录动态压力波动的能力相结合,为诊断和分类不同类型的青光眼揭示了新的眼压测量机会。