Juhász Arpád, Szilágyi Anna, Elso István, Tihanyi Zoltán, Paál Balázs, Altorjay Aron
Fejér Megyei Szent György Kórház Sebészeti Osztály, Székesfehévár.
Orv Hetil. 2005 Aug 7;146(32):1697-9.
Incidence of synchronous or metachronous carcinomas with primer esophageal malignancy together can be estimated at 17% and these disorders manifest mostly in the stomach.
The authors report the medical history of a 55-year-old man whose symptomatic middle third esophageal carcinoma was cured with esophagectomy and two field lymphadenectomy. Stomach was used for substitution. Histological examination verified pT2N1M0 tumor and metastasis of papillary thyroid carcinoma from the lymph node removed from near to the right recurrent nerve. Five weeks after the esophageal resection a total thyroidectomy and a central lymph node dissection was performed. The synchronous thyroid carcinoma was located into the inferior pole of right lobe. Currently the patient is without symptoms and plaints, the complex oncological treatment is in progress.
The incidence of a synchronous carcinoma of the esophagus and the thyroid gland is an extreme rarity. The basic difference connected to the tumorbiological behaviors of these two malignancies is found in the growing tendency and in the direction of lymphogen spreading. The common point is the recurrent nerve lymphatic chains in the thoracic dome. This is the reason that after the R0 resection of a middle third esophageal carcinoma the histological evaluation of a lymph node obtained from right recurrent nerve lymphatic chain shed light on the asymptomatic synchronous thyroid cancer.
In cases of operable esophageal carcinomas located into its middle or lower third the importance of a correct lymphadenectomy could not be emphasize enough. During the routine preoperative examinations it would be necessary to make cervical ultrasonography too.
同时或异时发生的原发性食管癌合并其他恶性肿瘤的发生率估计为17%,这些疾病大多发生在胃。
作者报告了一名55岁男性的病史,其有症状的中段食管癌通过食管切除术和两野淋巴结清扫术治愈,采用胃进行替代。组织学检查证实为pT2N1M0肿瘤,且从右侧喉返神经附近切除的淋巴结中有乳头状甲状腺癌转移。食管切除术后五周,进行了全甲状腺切除术和中央淋巴结清扫术。同步发生的甲状腺癌位于右叶下极。目前患者无症状及不适,综合肿瘤治疗正在进行中。
食管癌与甲状腺癌同步发生极为罕见。这两种恶性肿瘤在生长趋势和淋巴扩散方向上存在与肿瘤生物学行为相关的根本差异。共同点是胸廓顶部的喉返神经淋巴链。这就是在中段食管癌R0切除术后,对从右侧喉返神经淋巴链获取的淋巴结进行组织学评估能发现无症状同步甲状腺癌的原因。
对于位于食管中下段的可手术食管癌病例,正确的淋巴结清扫的重要性再怎么强调也不为过。在常规术前检查中,进行颈部超声检查也是必要的。