Jarvis James N
University of Oklahoma College of Medicine, Department of Pediatrics, Rheumatology Section, Oklahoma City, OK 73104, USA.
Expert Rev Mol Diagn. 2005 Sep;5(5):655-9. doi: 10.1586/14737159.5.5.655.
Rheumatoid arthritis and juvenile rheumatoid arthritis are histopathologically similar diseases characterized by chronic inflammation of the synovium. The pathogenesis of these diseases is unknown, but the emergence of gene expression profiling provides considerable promise that some of the complex, interconnected immunopathologic events underlying these diseases will soon be better understood. This review will summarize the potential use of gene expression profiling as a diagnostic or prognostic modality, and the potential benefits or limits of such uses. It will conclude with a short discussion of the potential for using gene expression profiling to identify novel targets of therapy in rheumatoid arthritis and related diseases.
类风湿性关节炎和青少年类风湿性关节炎在组织病理学上是相似的疾病，其特征是滑膜的慢性炎症。这些疾病的发病机制尚不清楚，但基因表达谱分析的出现提供了很大的希望，即这些疾病背后一些复杂的、相互关联的免疫病理事件很快将得到更好的理解。本综述将总结基因表达谱分析作为一种诊断或预后手段的潜在用途，以及这种用途的潜在益处或局限性。最后将简短讨论利用基因表达谱分析来识别类风湿性关节炎及相关疾病新治疗靶点的可能性。
