Beaty Michael W, Geisinger Kim R
Department of Pathology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157-1072, USA.
Cytojournal. 2005 Sep 8;2(1):13. doi: 10.1186/1742-6413-2-13.
Combining fine needle aspirate cytology with flow cytometry immunophenotyping for the rapid diagnosis of lymphoproliferative lesions is commonplace practice in many institutions. Yet, a definitive diagnosis of Hodgkin lymphoma in many cases remains elusive, requiring subsequent tissue biopsy confirmation. In this issue of CytoJournal, Hernandez et al explore the potential role of using the increased CD4/CD8 T-cell ratio in lymph node fine needle aspiration specimens as a specific feature in diagnosing Hodgkin lymphoma. CD4/CD8 T-cell ratio comparisons are made with cytomorphologic diagnoses of reactive, atypical, non-Hodgkin lymphoma, and Hodgkin lymphoma cases.
在许多机构中,将细针穿刺抽吸细胞学与流式细胞术免疫表型分析相结合用于快速诊断淋巴增生性病变是常见的做法。然而,在许多情况下,霍奇金淋巴瘤的明确诊断仍然难以确定,需要后续组织活检来证实。在本期《细胞杂志》中,埃尔南德斯等人探讨了在淋巴结细针穿刺标本中使用升高的CD4/CD8 T细胞比值作为诊断霍奇金淋巴瘤的一个特定特征的潜在作用。将CD4/CD8 T细胞比值与反应性、非典型、非霍奇金淋巴瘤和霍奇金淋巴瘤病例的细胞形态学诊断进行了比较。