Gupta Nalini, Nijhawan Raje, Srinivasan Radhika, Rajwanshi Arvind, Dutta Pinaki, Bhansaliy Anil, Sharma S C
Department of Cytopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Cytojournal. 2005 Dec 9;2:21. doi: 10.1186/1742-6413-2-21.
Primary lymphoma is an uncommon malignancy of the thyroid, comprising of 0.6 to 5 per cent of thyroid cancers in most series. Primary thyroid lymphomas (PTL) occur most commonly in elderly women and are commonly of B- cell origin. These frequently present in clinical stage IE and IIE. We report here ten cases of PTL diagnosed over a period of about 7 years in our institute. Out of these ten cases, nine were diagnosed on fine needle aspiration cytology (FNAC) and one case was misdiagnosed as lymphocytic thyroiditis. This case was diagnosed as Non- Hodgkin's lymphoma on surgical specimen. Five patients are disease free and doing well, while two died of disease and the other two were lost to follow-up. One patient is currently on chemotherapy. The salient clinical, biochemical, radiological features, FNA findings along with diagnostic difficulties are discussed.
原发性淋巴瘤是甲状腺的一种罕见恶性肿瘤，在大多数系列研究中占甲状腺癌的0.6%至5%。原发性甲状腺淋巴瘤（PTL）最常见于老年女性，通常起源于B细胞。这些病例在临床分期上多为IE期和IIE期。我们在此报告我院在约7年时间里诊断的10例PTL病例。在这10例病例中，9例通过细针穿刺细胞学检查（FNAC）确诊，1例被误诊为淋巴细胞性甲状腺炎。该病例经手术标本诊断为非霍奇金淋巴瘤。5例患者无病生存且情况良好，2例死于疾病，另外2例失访。1例患者目前正在接受化疗。本文讨论了其显著的临床、生化、放射学特征、细针穿刺检查结果以及诊断困难之处。
