Barker J H, Acland R D, Anderson G L, Patel J
Division of Plastic and Reconstructive Surgery (Department of Surgery), University of Louisville School of Medicine, KY.
Plast Reconstr Surg. 1992 Jul;90(1):95-102; discussion 103-4.
Following completion of arterial repair in an experimental free-flap model, platelet emboli have been observed passing through the microcirculation downstream. The purpose of this experimental study was to observe and quantitate changes in capillary perfusion occurring subsequent to these events. The isolated rat cremaster model was used. For 6 hours subsequent to surgical injury of the main artery in this model, the number of emboli and the number of perfused capillaries downstream were counted. In eight rats having an intentional arterial wall injury, emboli were consistently seen during the first hour of reflow. In the nine control animals having no arterial injury, no emboli were seen. The presence of emboli in the cremaster muscle, resulting from the arterial injury, was associated with a significant reduction in the number of perfused capillaries. We suggest that the observed decrease in capillary perfusion was associated with microemboli that produced an adverse effect for several hours after their initial presence in the circulation.
在一个实验性游离皮瓣模型中完成动脉修复后，已观察到血小板栓子通过下游的微循环。本实验研究的目的是观察和量化这些事件后发生的毛细血管灌注变化。采用分离的大鼠提睾肌模型。在该模型中，主动脉手术损伤后的6小时内，对栓子数量和下游灌注毛细血管数量进行计数。在8只故意造成动脉壁损伤的大鼠中，在再灌注的第一小时内始终能看到栓子。在9只没有动脉损伤的对照动物中，未观察到栓子。由动脉损伤导致的提睾肌中栓子的存在与灌注毛细血管数量的显著减少有关。我们认为，观察到的毛细血管灌注减少与微栓子有关，这些微栓子在最初进入循环后的几个小时内产生了不利影响。
