Golde William T, Pacheco Juan M, Duque Hernando, Doel Timothy, Penfold Barry, Ferman Geoffrey S, Gregg Douglas R, Rodriguez Luis L
Plum Island Animal Disease Center, Foot-and-Mouth Disease Unit PIADC, ARS, USDA P.O. Box 848 Greenport, NY 11944, USA.
Vaccine. 2005 Dec 30;23(50):5775-82. doi: 10.1016/j.vaccine.2005.07.043. Epub 2005 Aug 8.
Recent outbreaks of foot-and-mouth disease virus (FMDV) demonstrate that this highly contagious viral infection of cloven hoofed animals continues to be a significant economic problem worldwide. Debate about the most effective way to respond to outbreaks of FMDV in disease free countries continues to center on the use of vaccines. In this report, we present data showing that a commercially available, standard dose vaccine formulation can fully protect cattle against direct challenge with the virus in as little as 7 days with no carrier transmission to naïve animals. Cattle challenged 4 days after vaccination have reduced disease severity, no detectable virus in blood and little virus shedding from nasal secretions. These significant effects at 4 days post vaccination, confirmed in two separate trials, support the value of using currently available vaccines as a first line of defense against foot-and-mouth disease (FMD) outbreaks.
近期口蹄疫病毒（FMDV）的爆发表明，这种偶蹄动物的高度传染性病毒感染在全球范围内仍然是一个重大的经济问题。在无病国家，关于应对口蹄疫病毒爆发的最有效方法的争论仍集中在疫苗的使用上。在本报告中，我们展示的数据表明，一种市售的标准剂量疫苗制剂能够在短短7天内完全保护牛免受病毒的直接攻击，且不会将病毒传播给未感染的动物。接种疫苗4天后受到攻击的牛，疾病严重程度降低，血液中未检测到病毒，鼻腔分泌物中病毒排出量很少。在两项独立试验中得到证实的接种疫苗后4天出现的这些显著效果，支持了使用现有疫苗作为预防口蹄疫（FMD）爆发的第一道防线的价值。
