锰对 PK15 细胞和小鼠体内口蹄疫病毒的抗病毒作用。
Antiviral Effect of Manganese against Foot-and-Mouth Disease Virus Both in PK15 Cells and Mice.
机构信息
State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, NO1 Xujiaping, Yanchangbu, Lanzhou 730046, China.
College of Animal Husbandry and Veterinary Medicine, Southwest Minzu University, Chengdu 610041, China.
出版信息
Viruses. 2023 Jan 30;15(2):390. doi: 10.3390/v15020390.
Foot-and-mouth disease (FMD) is an acute contagious disease of cloven-hoofed animals such as cattle, pigs, and sheep. Current emergency FMD vaccines are of limited use for early protection because their protective effect starts 7 days after vaccination. Therefore, antiviral drugs or additives are used to rapidly stop the spread of the virus during FMD outbreaks. Manganese (Mn) was recently found to be an important substance necessary for the host to protect against DNA viruses. However, its antiviral effect against RNA viruses remains unknown. In this study, we found that Mn has antiviral effects on the FMD virus (FMDV) both in PK15 cells and mice. The inhibitory effect of Mn on FMDV involves NF-κB activation and up-regulation of interferon-stimulated genes. Animal experiments showed that Mn can be highly effective in protecting C57BL/6N mice from being infected with FMDV. Overall, we suggest Mn as an effective antiviral additive for controlling FMDV infection.
口蹄疫（FMD）是一种偶蹄类动物（如牛、猪和羊）的急性传染病。目前的应急口蹄疫疫苗的早期保护作用有限，因为其保护效果在接种后 7 天开始。因此，在口蹄疫爆发期间，抗病毒药物或添加剂被用于迅速阻止病毒的传播。最近发现，锰（Mn）是宿主抵抗 DNA 病毒所必需的重要物质。然而，其对 RNA 病毒的抗病毒作用尚不清楚。在这项研究中，我们发现 Mn 对 PK15 细胞和小鼠中的口蹄疫病毒（FMDV）均具有抗病毒作用。Mn 对 FMDV 的抑制作用涉及 NF-κB 激活和干扰素刺激基因的上调。动物实验表明，Mn 可高度有效地保护 C57BL/6N 小鼠免受 FMDV 感染。总的来说，我们认为 Mn 是一种有效的控制 FMDV 感染的抗病毒添加剂。
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