Evans D G R, Birch J M, Ramsden R T, Sharif S, Baser M E
Academic Unit of Medical Genetics and Regional Genetic Service, St Mary's Hospital (SM2), Hathersage Road, Manchester, M13 OJH, UK.
J Med Genet. 2006 Apr;43(4):289-94. doi: 10.1136/jmg.2005.036319. Epub 2005 Sep 9.
In recent years the use of radiation treatment for benign tumours has increased with the advent of stereotactic delivery and, in particular, single high dose gamma knife therapy. This has been particularly true for benign CNS (central nervous system) tumours such as vestibular schwannoma, meningioma, pituitary adenoma, and haemangioblastoma. While short term follow up in patients with isolated tumours suggests this treatment is safe, there are particular concerns regarding its use in childhood and in tumour predisposing syndromes. We have reviewed the use of radiation treatment in these contexts with particular regard to malignant transformation and new tumour induction. This review indicates that much more caution is warranted regarding the use of radiation treatment for benign tumours in childhood and in tumour prone conditions such as the neurofibromatoses.
近年来，随着立体定向放射治疗技术的出现，尤其是单次大剂量伽玛刀治疗的应用，良性肿瘤的放射治疗使用有所增加。对于良性中枢神经系统（CNS）肿瘤，如前庭神经鞘瘤、脑膜瘤、垂体腺瘤和血管母细胞瘤，情况尤其如此。虽然对孤立性肿瘤患者的短期随访表明这种治疗是安全的，但对于其在儿童期和肿瘤易感综合征中的应用仍存在特殊担忧。我们回顾了在这些情况下放射治疗的使用，特别关注恶性转化和新肿瘤的诱导。这篇综述表明，在儿童期以及神经纤维瘤病等肿瘤易患疾病中，对于良性肿瘤使用放射治疗需要更加谨慎。
