Anduleit Karin, Sutton Geoff, Diprose Jonathan M, Mertens Peter P C, Grimes Jonathan M, Stuart David I
Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
Protein Sci. 2005 Oct;14(10):2741-3. doi: 10.1110/ps.051516405. Epub 2005 Sep 9.
Many insect viruses survive for long periods by occlusion within robust crystalline polyhedra composed primarily of a single polyhedrin protein. We show that two different virus families form polyhedra which, despite lack of sequence similarity in the virally encoded polyhedrin protein, have identical cell constants and a body-centered cubic lattice. It is almost inconceivable that this could have arisen by chance, suggesting that the crystal lattice has been preserved because it is particularly well-suited to its function of packaging and protecting viruses.
许多昆虫病毒通过包裹在主要由单一多角体蛋白构成的坚固晶体多角体内而长期存活。我们发现，两个不同的病毒科形成了多角体，尽管病毒编码的多角体蛋白缺乏序列相似性，但它们具有相同的晶胞常数和体心立方晶格。这种情况几乎不可能是偶然出现的，这表明晶格得以保留是因为它特别适合其包装和保护病毒的功能。
