中风后抑郁症风险的量化：意大利多中心观察性研究DESTRO。
Quantification of the risk of post stroke depression: the Italian multicenter observational study DESTRO.
作者信息
Paolucci S, Gandolfo C, Provinciali L, Torta R, Sommacal S, Toso V
机构信息
S. Lucia Foundation - I.R.C.C.S., Rome, Italy.
出版信息
Acta Psychiatr Scand. 2005 Oct;112(4):272-8. doi: 10.1111/j.1600-0447.2005.00590.x.
OBJECTIVE
The Italian multicenter observational study depression in stroke (DESTRO) aimed to identify risk factors for post stroke depression (PSD) and quantify the likelihood of it arising in various categories of patients.
METHOD
Mood evaluation was performed in 1064 consecutive stroke patients by means of Beck Depression Inventory and Visual Analog Mood Scale. Depressive symptoms were classified using the DSM-IV and revised WHO criteria for depression in the course of a neurological disorder.
RESULTS
Post stroke depression was seen in 36% of the survivors, with dysthymia by far the predominant form (80.7%). Female sex, disability, previous cerebrovascular or depressive episodes were significantly associated with an increased risk of depression. Combinations of these factors raised the risk of PSD exponentially, from 24.3 to 89.1%. The site of the stroke did not come into the uni- or multivariate analysis.
CONCLUSION
At admission, it is possible to predict the likelihood of PSD and quantify the relative risk.
目的
意大利多中心卒中后抑郁观察性研究（DESTRO）旨在确定卒中后抑郁（PSD）的危险因素，并量化其在各类患者中发生的可能性。
方法
采用贝克抑郁量表和视觉模拟情绪量表对1064例连续的卒中患者进行情绪评估。使用《精神疾病诊断与统计手册》第四版（DSM-IV）和修订后的世界卫生组织（WHO）关于神经疾病过程中抑郁的标准对抑郁症状进行分类。
结果
36%的幸存者出现了卒中后抑郁，其中心境恶劣是最主要的形式（80.7%）。女性、残疾、既往脑血管事件或抑郁发作与抑郁风险增加显著相关。这些因素的组合使PSD的风险呈指数级上升，从24.3%升至89.1%。卒中部位未纳入单因素或多因素分析。
结论
在入院时，可以预测PSD的可能性并量化相对风险。
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