Chaturvedi Poonam, Tiwari Vandana, Singh Ajai Kumar, Qavi Abdul, Thacker Anup Kumar
Department of Neurology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
Department of Biochemistry Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
J Family Med Prim Care. 2020 Aug 25;9(8):4039-4044. doi: 10.4103/jfmpc.jfmpc_273_20. eCollection 2020 Aug.
Depression following a stroke/poststroke depression (PSD) has been newly recognized as one of the most common complications after stroke. PSD may affect neuroplasticity and quality of life. The purpose of present study was to find out effects of depression on functional recovery, quality of life and neuroplasticity in patients with acute stroke.
A total of 76 cases were recruited for the study and out of which 44 were available for the analysis after six months. Patients were divided into three groups according to severity of depression: Group A (without depression), Group B (mild-to-moderate depression), and Group C (severe depression) on the basis of Patient Health Questionnaire-9 (PHQ-9) scale scores. All patients were assessed for depression by PHQ-9, and for quality of life by Stroke Specific Quality of Life (SSQOL) scale. Neuroplasticity was assessed by measuring levels of serum brain-derived neurotrophic factor.
Quality of life was observed to be significantly affected by depression ( ≤ 0.05). The most commonly affected characteristics were energy, family roles, mobility, self-care, social roles, upper extremity function, and work productivity. Serum BDNF levels were also affected significantly by depression ( ≤ 0.05).
PSD is a serious complication, affecting quality of life and neuroplasticity (BDNF) in patients. Decreased neuroplasticity further may affect functional improvement.
中风后抑郁（PSD）已被新确认为中风后最常见的并发症之一。PSD可能会影响神经可塑性和生活质量。本研究的目的是探讨抑郁对急性中风患者功能恢复、生活质量和神经可塑性的影响。
本研究共纳入76例患者，其中44例在6个月后可进行分析。根据患者健康问卷-9（PHQ-9）量表评分，将患者按抑郁严重程度分为三组：A组（无抑郁）、B组（轻度至中度抑郁）和C组（重度抑郁）。所有患者均采用PHQ-9评估抑郁情况，采用卒中特异性生活质量（SSQOL）量表评估生活质量。通过测量血清脑源性神经营养因子水平评估神经可塑性。
观察到生活质量受抑郁影响显著（≤0.05）。最常受影响的特征包括精力、家庭角色、活动能力、自我护理、社会角色、上肢功能和工作效率。血清BDNF水平也受抑郁影响显著（≤0.05）。
PSD是一种严重的并发症，会影响患者的生活质量和神经可塑性（BDNF）。神经可塑性降低可能进一步影响功能改善。
