Koh Adeline Loo Yee, Sun Chun Xiang, Zhu Fei, Glogauer Michael
Faculty of Dentistry, University of Toronto, Toronto, Canada.
Cell Immunol. 2005 Jun;235(2):92-7. doi: 10.1016/j.cellimm.2005.07.005. Epub 2005 Sep 12.
The small Rho guanosine triphosphatases (GTPases) Rac1 and Rac2 have distinct roles in regulating neutrophil chemotaxis; however, little is known about their possible unique roles in mediating bacterial killing. To elucidate the relative roles of Rac1 and Rac2 in regulating neutrophil-mediated bacterial killing, we utilized the previously described mice model in which mouse neutrophils are deficient in either Rac1, Rac2, or both isoforms. We demonstrate here that while both Rac isoforms are required for normal neutrophil chemotaxis and bacterial killing, they have non-overlapping roles in bacterial phagocytosis and NADPH oxidase function.
小Rho鸟苷三磷酸酶（GTP酶）Rac1和Rac2在调节中性粒细胞趋化性方面具有不同作用；然而，对于它们在介导细菌杀伤中可能的独特作用却知之甚少。为了阐明Rac1和Rac2在调节中性粒细胞介导的细菌杀伤中的相对作用，我们利用了先前描述的小鼠模型，其中小鼠中性粒细胞缺乏Rac1、Rac2或两种异构体。我们在此证明，虽然两种Rac异构体对于正常中性粒细胞趋化性和细菌杀伤都是必需的，但它们在细菌吞噬作用和NADPH氧化酶功能中具有不重叠的作用。
