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阿司匹林抵抗性包膜警告综合征中的口服氯吡格雷负荷量

Oral clopidogrel load in aspirin-resistant capsular warning syndrome.

作者信息

Fahey Christopher D, Alberts Mark J, Bernstein Richard A

机构信息

Ken and Ruth Davee Department of Neurology and Clinical Neurological Sciences, Feinberg School of Medicine of Northwestern University, Chicago, IL 60611, USA.

出版信息

Neurocrit Care. 2005;2(2):183-4. doi: 10.1385/NCC:2:2:183.

DOI:10.1385/NCC:2:2:183
PMID:16159063
Abstract

INTRODUCTION

Capsular warning syndrome (CWS) carries a significant risk of permanent stroke. There are no proven therapies for preventing completed stroke in this unstable situation.

METHODS

Clinical observation in two patients with aspirin-resistant CWS treated with a loading dose of oral clopidogrel.

RESULTS

Both patients had excellent neurological outcome, although one sustained an asymptomatic brain infarction.

CONCLUSION

High-dose oral clopidogrel plus aspirin merits formal evaluation in high-risk transient brain ischemia such as CWS, preferably in a randomized trial compared to aspirin alone.

摘要

引言

包膜警告综合征（CWS）具有永久性中风的重大风险。在这种不稳定情况下，尚无经证实的预防中风完全发作的疗法。

方法

对两名阿司匹林抵抗性CWS患者给予口服氯吡格雷负荷剂量进行临床观察。

结果

两名患者神经功能预后均良好，尽管其中一名发生了无症状性脑梗死。

结论

高剂量口服氯吡格雷加阿司匹林值得在诸如CWS等高风险短暂性脑缺血中进行正式评估，最好与单独使用阿司匹林进行随机试验对比。

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