在锥形合成纳米孔中检测单个卟啉分子。

Detecting single porphyrin molecules in a conically shaped synthetic nanopore.

作者信息

Heins Elizabeth A, Siwy Zuzanna S, Baker Lane A, Martin Charles R

机构信息

Department of Chemistry and Center for Research at the Bio/Nano Interface, University of Florida, Gainesville, Florida 32611-7200, USA.

出版信息

Nano Lett. 2005 Sep;5(9):1824-9. doi: 10.1021/nl050925i.

DOI:10.1021/nl050925i

PMID:16159231

Abstract

We report here the first example of abiotic resistive-pulse sensing of a molecular (as opposed to a particle or macromolecular) analyte. This was accomplished by using a conically shaped nanopore prepared by the track-etch method as the sensing element. It is possible to sense the molecular analyte because the small diameter opening of the conical nanopore (approximately 4.5 nm) is comparable to the diameter of the analyte molecule (approximately 2 nm).

摘要

我们在此报告分子（与颗粒或大分子相对）分析物的非生物电阻脉冲传感的首个实例。这是通过使用径迹蚀刻法制备的锥形纳米孔作为传感元件来实现的。能够传感分子分析物是因为锥形纳米孔的小直径开口（约4.5纳米）与分析物分子的直径（约2纳米）相当。