Clarke Nicholas A, Francis Paul T
West Kent NHS and Social Care Trust, King's Hill, Kent, UK.
Expert Rev Neurother. 2005 Sep;5(5):671-82. doi: 10.1586/14737175.5.5.671.
The pathology and clinical symptoms of Alzheimer's disease are well known and include plaques, tangles, cell loss and dysfunction. The target of current treatments is to improve neuronal dysfunction and produce symptomatic benefits based on a clear understanding of neurotransmitter biochemistry. The purpose of this review is to examine the scientific background to currently available treatments, discuss the clinical experience of employing these drugs in Alzheimer's disease patients and review the socioeconomic influences on their use in the future.
阿尔茨海默病的病理学和临床症状已为人熟知，包括斑块、缠结、细胞丢失和功能障碍。当前治疗的目标是在清楚了解神经递质生物化学的基础上改善神经元功能障碍并产生症状缓解效果。本综述的目的是审视现有治疗方法的科学背景，讨论在阿尔茨海默病患者中使用这些药物的临床经验，并回顾未来其使用的社会经济影响。
