Rapid Response Radiotherapy Program, Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
Support Care Cancer. 2012 Sep;20(9):2121-7. doi: 10.1007/s00520-011-1322-6. Epub 2011 Nov 12.
The purpose of this study is to compare self-reported quality of life (QOL) scores in old and young patients with metastatic cancer using the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C15-PAL questionnaire.
Patients receiving palliative radiotherapy (RT) for bone metastases and brain metastases completed the QLQ-C15-PAL questionnaire prior to treatment. Using multiple linear regression analysis, a parametric test, the QLQ-C15-PAL scores were compared using 65 and 70 years as cutoff ages.
A total of 340 patients were referred for palliative RT for bone metastases (n = 190) or brain metastases (n = 150). Physical functioning and appetite were worse in the older group using either 65 or 70 years as the cutoff age. Age-related differences in the QLQ-C15-PAL scores varied as a function of age cutoff used and location of metastatic site irradiated.
Based on the (EORTC) QLQ-C15-PAL, elderly advanced cancer patients have a different QOL profile. Similar observations have been reported with the (EORTC) QLQ-C30 questionnaire.
本研究旨在使用欧洲癌症研究与治疗组织（EORTC）生活质量问卷核心 15 项（QLQ-C15-PAL）比较老年和年轻转移性癌症患者的自我报告生活质量（QOL）评分。
接受姑息性放疗（RT）治疗骨转移和脑转移的患者在治疗前完成了 QLQ-C15-PAL 问卷。使用多元线性回归分析、参数检验，以 65 岁和 70 岁为截止年龄比较 QLQ-C15-PAL 评分。
共有 340 名患者因骨转移（n = 190）或脑转移（n = 150）接受姑息性 RT。使用 65 岁或 70 岁作为截止年龄，老年组的身体功能和食欲较差。与使用的年龄截止值和照射转移部位有关，QLQ-C15-PAL 评分的年龄相关差异因年龄截止值而异。
基于 EORTC QLQ-C15-PAL，老年晚期癌症患者具有不同的 QOL 特征。在 EORTC QLQ-C30 问卷中也有类似的观察结果。
