骨质疏松症患者胶原蛋白吡啶交联的尿排泄及骨折的影响。
Urinary excretion of pyridinium crosslinks of collagen in patients with osteoporosis and the effects of bone fracture.
作者信息
McLaren A M, Hordon L D, Bird H A, Robins S P
机构信息
Rowett Research Institute, Bucksburn, Aberdeen, United Kingdom.
出版信息
Ann Rheum Dis. 1992 May;51(5):648-51. doi: 10.1136/ard.51.5.648.
Abstract
Values for the urinary excretion of pyridinium crosslinks of collagen, pyridinoline and deoxypyridinoline, in a group of 30 elderly women with femoral fractures associated with osteoporosis and a group of 20 women without recent fracture but with overt or suspected osteoporosis were compared with 27 control subjects matched for age. Relative to the control group, the excretion of the crosslinks was significantly higher in the group with fractures and the group with osteoporosis. Fractures contributed markedly to the excretion of pyridinium crosslinks as the patients with fractures showed significantly higher excretion of pyridinoline and deoxypyridinoline than the group without recent fractures. This was confirmed by the fact that excretion of pyridinium crosslinks in patients with accidental bone fractures was significantly higher than for healthy control subjects matched for age and sex. The crosslinks appear to provide valid indices of bone resorption, but the effects of bone fracture must be considered in the clinical application of this technique.
摘要
将一组30名患有与骨质疏松症相关的股骨骨折的老年女性和一组20名近期无骨折但有明显或疑似骨质疏松症的女性的尿中胶原吡啶交联物（吡啶啉和脱氧吡啶啉）排泄值，与27名年龄匹配的对照受试者进行了比较。相对于对照组，骨折组和骨质疏松组的交联物排泄量显著更高。骨折对吡啶交联物的排泄有显著影响，因为骨折患者的吡啶啉和脱氧吡啶啉排泄量明显高于近期无骨折的组。意外骨折患者的吡啶交联物排泄量显著高于年龄和性别匹配的健康对照受试者，这一事实证实了上述结果。交联物似乎可作为骨吸收的有效指标，但在该技术的临床应用中必须考虑骨折的影响。
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