吡啶交联物的排泄与早期类风湿关节炎的疾病活动度及四肢骨丢失相关。
Excretion of pyridinium crosslinks correlates with disease activity and appendicular bone loss in early rheumatoid arthritis.
作者信息
Gough A K, Peel N F, Eastell R, Holder R L, Lilley J, Emery P
机构信息
Department of Rheumatology, University of Birmingham, United Kingdom.
出版信息
Ann Rheum Dis. 1994 Jan;53(1):14-7. doi: 10.1136/ard.53.1.14.
Abstract
OBJECTIVE
To establish if urinary excretion rates of the collagen crosslinks pyridinoline and deoxypyridinoline, which are known to be elevated in established rheumatoid arthritis (RA), are useful markers of bone loss in this disease.
METHODS
Eight hour urine collections on all patients and 52 controls were performed, and the rates of pyridinoline and deoxypyridinoline excretion were measured. Bone mineral density (BMD), by dual energy x-ray absorption, and full laboratory and clinical assessments were performed.
RESULTS
The rates of excretion of pyridinoline and deoxypyridinoline were significantly increased in patients compared with controls (p < 0.001). Pyridinoline excretion was associated with increased disease activity (ESR/CRP) but not disability (HAQ score/Functional Grade), and correlated with BMD loss at the femoral neck (p < 0.01).
CONCLUSION
The excretion of collagen crosslinks may be useful as markers of bone and cartilage turnover in patients with RA.
摘要
目的
确定在已确诊的类风湿关节炎（RA）中已知会升高的胶原交联物吡啶啉和脱氧吡啶啉的尿排泄率是否为此疾病中骨质流失的有用标志物。
方法
对所有患者和52名对照者进行8小时尿液收集，并测量吡啶啉和脱氧吡啶啉的排泄率。通过双能X线吸收法测量骨矿物质密度（BMD），并进行全面的实验室和临床评估。
结果
与对照者相比，患者的吡啶啉和脱氧吡啶啉排泄率显著升高（p < 0.001）。吡啶啉排泄与疾病活动度增加（血沉/CRP）相关，但与残疾程度（健康评估问卷评分/功能分级）无关，且与股骨颈骨密度降低相关（p < 0.01）。
结论
胶原交联物的排泄可能作为类风湿关节炎患者骨和软骨周转的标志物。
相似文献
1
Excretion of pyridinium crosslinks correlates with disease activity and appendicular bone loss in early rheumatoid arthritis.吡啶交联物的排泄与早期类风湿关节炎的疾病活动度及四肢骨丢失相关。
Ann Rheum Dis. 1994 Jan;53(1):14-7. doi: 10.1136/ard.53.1.14.
2
Urinary excretion of pyridinium crosslinks of collagen correlated with joint damage in arthritis.胶原蛋白吡啶交联物的尿排泄量与关节炎中的关节损伤相关。
Br J Rheumatol. 1994 Jan;33(1):11-5. doi: 10.1093/rheumatology/33.1.11.
3
Hydroxypyridinium collagen crosslinks in serum, urine, synovial fluid and synovial tissue in patients with rheumatoid arthritis compared with osteoarthritis.与骨关节炎患者相比，类风湿关节炎患者血清、尿液、滑液和滑膜组织中的羟基吡啶鎓胶原蛋白交联物。
Rheumatology (Oxford). 2003 Feb;42(2):314-20. doi: 10.1093/rheumatology/keg102.
4
The urinary excretion of pyridinoline and deoxypyridinoline during rheumatoid arthritis therapy with infliximab.英夫利昔单抗治疗类风湿关节炎期间吡啶啉和脱氧吡啶啉的尿排泄情况。
Clin Rheumatol. 2004 Jun;23(3):214-7. doi: 10.1007/s10067-003-0856-5. Epub 2004 Feb 26.
5
The effects of sulphasalazine on urinary excretion of the hydroxypyridinium crosslinks of collagen in patients with rheumatoid arthritis.柳氮磺胺吡啶对类风湿关节炎患者尿中胶原羟基吡啶交联物排泄的影响。
Yonsei Med J. 2002 Aug;43(4):435-40. doi: 10.3349/ymj.2002.43.4.435.
6
Urinary excretion of pyridinium crosslinks of collagen in patients with osteoporosis and the effects of bone fracture.骨质疏松症患者胶原蛋白吡啶交联的尿排泄及骨折的影响。
Ann Rheum Dis. 1992 May;51(5):648-51. doi: 10.1136/ard.51.5.648.
7
[Collagen breakdown in ankylosing spondylitis-relationship to disease related parameters].[强直性脊柱炎中的胶原蛋白分解——与疾病相关参数的关系]
Z Rheumatol. 2003 Oct;62(5):459-67. doi: 10.1007/s00393-003-0490-2.
8
Relationship between urinary pyridinium cross-links, disease activity and disease subsets of ankylosing spondylitis.强直性脊柱炎患者尿吡啶交联物与疾病活动度及疾病亚型之间的关系
Rheumatology (Oxford). 1999 Jan;38(1):21-7. doi: 10.1093/rheumatology/38.1.21.
9
Pyridinium crosslinks excretion in patients with rheumatoid arthritis. Correlation with disease activity and glucocorticoid treatment.
Adv Exp Med Biol. 1999;455:227-33. doi: 10.1007/978-1-4615-4857-7_33.
10
Collagen cross-link metabolites in urine as markers of bone metastases in prostatic carcinoma.尿中胶原蛋白交联代谢产物作为前列腺癌骨转移的标志物
J Urol. 1994 Apr;151(4):909-13. doi: 10.1016/s0022-5347(17)35120-0.
引用本文的文献
1
Clinical significance of quantitative bone SPECT/CT in the evaluation of hand and wrist pain in patients with rheumatic disease.定量骨 SPECT/CT 在评估风湿性疾病患者手和腕部疼痛中的临床意义。
Sci Rep. 2022 Jan 10;12(1):327. doi: 10.1038/s41598-021-03874-9.
2
Serum Pyridinoline is Associated With Radiographic Joint Erosions in Rheumatoid Arthritis.血清吡啶啉与类风湿关节炎的影像学关节侵蚀相关。
Arch Rheumatol. 2019 Apr 22;34(4):387-394. doi: 10.5606/ArchRheumatol.2019.7243. eCollection 2019 Dec.
3
Effects of denosumab on bone mineral density and bone turnover markers in rheumatoid arthritis patients switching from bisphosphonates.地诺单抗对从双膦酸盐转换治疗的类风湿关节炎患者骨密度和骨转换标志物的影响。
J Exp Orthop. 2019 Oct 29;6(1):41. doi: 10.1186/s40634-019-0211-7.
4
A TRAF6 genetic variant is associated with low bone mineral density in rheumatoid arthritis.TRAF6 基因变异与类风湿关节炎患者的低骨密度相关。
Clin Rheumatol. 2019 Apr;38(4):1067-1074. doi: 10.1007/s10067-018-4362-1. Epub 2018 Dec 1.
5
Yi Shen Juan Bi Pill Ameliorates Bone Loss and Destruction Induced by Arthritis Through Modulating the Balance of Cytokines Released by Different Subpopulations of T Cells.益肾蠲痹丸通过调节不同亚群T细胞释放的细胞因子平衡来改善关节炎引起的骨质流失和破坏。
Front Pharmacol. 2018 Mar 27;9:262. doi: 10.3389/fphar.2018.00262. eCollection 2018.
6
CTLA-4Ig-induced T cell anergy promotes Wnt-10b production and bone formation in a mouse model.CTLA-4Ig 诱导的 T 细胞失能促进了小鼠模型中 Wnt-10b 的产生和骨形成。
Arthritis Rheumatol. 2014 Apr;66(4):990-9. doi: 10.1002/art.38319.
7
Systemic bone effects of biologic therapies in rheumatoid arthritis and ankylosing spondylitis.生物疗法治疗类风湿关节炎和强直性脊柱炎的全身骨骼效应。
Osteoporos Int. 2011 Apr;22(4):1023-36. doi: 10.1007/s00198-010-1462-4. Epub 2010 Oct 20.
8
Influence of Rituximab on markers of bone remodeling in patients with rheumatoid arthritis: a prospective open-label pilot study.利妥昔单抗对类风湿关节炎患者骨重塑标志物的影响：一项前瞻性开放标签初步研究。
Rheumatol Int. 2011 Feb;31(2):269-72. doi: 10.1007/s00296-010-1560-9. Epub 2010 Jul 27.
9
A novel T cell cytokine, secreted osteoclastogenic factor of activated T cells, induces osteoclast formation in a RANKL-independent manner.一种新型T细胞细胞因子，即活化T细胞分泌的破骨细胞生成因子，以一种不依赖RANKL的方式诱导破骨细胞形成。
Arthritis Rheum. 2009 Nov;60(11):3324-35. doi: 10.1002/art.24877.
10
Impact of low-dose prednisolone on bone synthesis and resorption in early rheumatoid arthritis: experiences from a two-year randomized study.低剂量泼尼松龙对早期类风湿关节炎骨合成与骨吸收的影响：一项为期两年的随机研究经验
Arthritis Res Ther. 2008;10(6):R128. doi: 10.1186/ar2542. Epub 2008 Nov 5.
本文引用的文献
1
TRANSPARENT SKIN AND OSTEOPOROSIS: A STUDY IN PATIENTS WITH RHEUMATOID DISEASE.透明皮肤与骨质疏松症：类风湿病患者的一项研究。
Ann Rheum Dis. 1965 May;24(3):219-23. doi: 10.1136/ard.24.3.219.
2
The early radiological signs of rheumatoid arthritis.类风湿关节炎的早期放射学征象。
Bull Rheum Dis. 1960 Nov;11:231-4.
3
Physiological variations in the urinary excretion of pyridinium crosslinks of collagen.
Br J Rheumatol. 1993 Apr;32(4):307-12. doi: 10.1093/rheumatology/32.4.307.
4
Total body calcium in rheumatoid arthritis: effects of disease activity and corticosteroid treatment.类风湿关节炎患者的全身钙含量：疾病活动度及皮质类固醇治疗的影响
Br Med J (Clin Res Ed). 1982 Jul 31;285(6338):330-2. doi: 10.1136/bmj.285.6338.330.
5
Quantitation of hydroxypyridinium crosslinks in collagen by high-performance liquid chromatography.通过高效液相色谱法定量测定胶原蛋白中的羟基吡啶交联物
Anal Biochem. 1984 Mar;137(2):380-8. doi: 10.1016/0003-2697(84)90101-5.
6
Fractures after rheumatoid arthritis. A population-based study.类风湿关节炎后的骨折。一项基于人群的研究。
Arthritis Rheum. 1984 Dec;27(12):1353-61. doi: 10.1002/art.1780271205.
7
Prevalence of decreased bone mass in rheumatoid arthritis. Relation to anti-inflammatory treatment.类风湿关节炎中骨量减少的患病率。与抗炎治疗的关系。
Clin Rheumatol. 1984 Jun;3(2):201-8. doi: 10.1007/BF02030755.
8
Osteoporosis of rheumatoid arthritis: influence of age, sex and corticosteroids.类风湿关节炎的骨质疏松症：年龄、性别及皮质类固醇的影响
Arthritis Rheum. 1967 Oct;10(5):423-30. doi: 10.1002/art.1780100504.
9
Osteoporosis in rheumatoid arthritis. A follow-up study.类风湿关节炎中的骨质疏松症。一项随访研究。
Acta Rheumatol Scand. 1968;14(4):276-84. doi: 10.3109/rhe1.1968.14.issue-1-4.30.
10
Osteoporosis in rheumatoid arthritis.类风湿关节炎中的骨质疏松症
Calcif Tissue Res. 1970;5(4):327-32. doi: 10.1007/BF02017562.
Zotero 插件