Saldías P Fernando, Pavié G Juana
Departamento de Enfermedades Respiratorias, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Rev Chilena Infectol. 2005;22 Suppl 1:s39-45. Epub 2005 Sep 13.
Clinical evolution in patients affected by community acquired pneumonia varies from a mild and low risk infectious disease to an extremely severe, life threatening disease. Commonly, immunocompetent adults without co-morbidities or severe risk factors cared for at out patient clinic have low risk of complications and death (mortality below 1-2%); it increases to 5-15% in patients with co-morbidities and/or with specific risk factors that are admitted into the hospital and reaches 20-50% in those patients admitted into ICUs. Evaluation of severity in patients with pneumonia allows the prediction of disease evolution, establishing the proper setting of care, the type- of microbiological tests needed, and to choose the best empiric antibiotic treatment. It is suggested that patients be in three risk categories: low risk (mortality under 1-2%) susceptible to ambulatory treatment; high risk patients (mortality 20-30%) that need specialized wards; and intermediate risk patients, with co-morbidities and/or risk factors for complicated clinical evolution and death, but cannot be classified in a specific category. In the ambulatory setting, without availability of complete laboratory exams, it is recommended to evaluating the severity of pneumonia considering the following clinical variables: age over 65 years, presence of co-morbidities, sensorial compromise, vital signs alteration, degree of radiological involvement: multilobar, bilateral findings, cavitations), pleural effusion and arterial oximetry < 90%. However, clinical judgement and the physician's experience must predominate over predictive models, which are not infallible.
社区获得性肺炎患者的临床病程差异很大,从轻度、低风险的感染性疾病到极其严重、危及生命的疾病。通常,在门诊接受治疗的无合并症或严重风险因素的免疫功能正常的成年人发生并发症和死亡的风险较低(死亡率低于1%-2%);合并症和/或有特定风险因素且需住院治疗的患者,死亡率增至5%-15%;入住重症监护病房的患者,死亡率达20%-50%。评估肺炎患者的严重程度有助于预测疾病的病程,确定合适的治疗环境、所需的微生物检测类型,并选择最佳的经验性抗生素治疗方案。建议将患者分为三类风险:低风险(死亡率低于1%-2%),适合门诊治疗;高风险患者(死亡率20%-30%),需要专科病房;以及中度风险患者,有合并症和/或复杂临床病程及死亡的风险因素,但无法归为特定类别。在门诊环境中,若无法进行全面的实验室检查,建议考虑以下临床变量来评估肺炎的严重程度:年龄超过65岁、存在合并症、感觉功能受损、生命体征改变、放射学累及程度(多叶、双侧表现、空洞形成)、胸腔积液以及动脉血氧饱和度<90%。然而,临床判断和医生的经验必须比预测模型更具主导性,因为预测模型并非绝对可靠。