van der Bij Gerben J, Oosterling Steven J, Meijer Sybren, Beelen Robert H J, van Egmond Marjolein
Department of Surgical Oncology, VU University Medical Center, Amsterdam, The Netherlands.
Immunobiology. 2005;210(2-4):259-65. doi: 10.1016/j.imbio.2005.05.020.
Development of liver metastases is a frequent complication in the course of gastro-intestinal malignancies. After entering the liver via the portal circulation, blood-borne tumor cells that have been seeded from primary colorectal cancer, are first encountered by Kupffer cells (KC), which line the liver sinusoids. KC represent approximately 10% of all liver cells, and have the ability to kill tumor cells. As such, they may play an important intrinsic role in the protection against outgrowth of hepatic metastases. Furthermore, the cytotoxic function of KC is increased upon stimulation with various biological response modifiers, such as interferon-gamma, granulocyte macrophage-colony stimulating factor, antibodies and muramyl dipeptides. Therefore, enhancement of KC cytotoxic functions may represent an attractive treatment modality to prevent development of liver metastases in the clinical setting.
肝转移是胃肠道恶性肿瘤病程中常见的并发症。从原发性结直肠癌播散而来的血行肿瘤细胞经门静脉循环进入肝脏后，首先会遇到肝窦内衬的库普弗细胞（KC）。KC约占肝脏所有细胞的10%，具有杀伤肿瘤细胞的能力。因此，它们可能在预防肝转移瘤生长方面发挥重要的内在作用。此外，在用各种生物反应调节剂（如γ干扰素、粒细胞巨噬细胞集落刺激因子、抗体和胞壁酰二肽）刺激后，KC的细胞毒性功能会增强。因此，增强KC的细胞毒性功能可能是临床环境中预防肝转移发生的一种有吸引力的治疗方式。
