停用外源性糖皮质激素后的短期生长情况。

Short-term growth after withdrawal of exogenous glucocorticoids.

作者信息

Wolthers Ole D, Schou Anders J

机构信息

Children's Clinic Randers, Randers, Denmark.

出版信息

Horm Res. 2005;64(3):116-8. doi: 10.1159/000088348. Epub 2005 Sep 15.

DOI:10.1159/000088348

PMID:16166782

Abstract

BACKGROUND

The growth-suppressive effect of systemic glucocorticoids in children is well established, however, recovery of growth after withdrawal of short-term treatment in school-age children has not been evaluated.

OBJECTIVE

To assess short-term growth after withdrawal of systemic glucocorticoids.

METHODS

A post-hoc analysis of data from a double-blind lower leg growth trial which compared 5 mg prednisolone once daily in the evening with placebo was performed. The study consisted of run-in, treatment, wash-out and run-out periods of 1 week duration. In 10 children with asthma (mean age 11 years) lower leg growth measured with the knemometer could be studied up to 3 weeks after withdrawal of prednisolone.

RESULTS

Mean (SEM) lower leg growth rates during run-in, prednisolone treatment and the first, second and third weeks after withdrawal of prednisolone were 0.48 (0.15), -0.27 (0.20), 0.53 (0.19), 0.72 (0.16) and 0.66 (0.14) mm/week, p < 0.001. Mean growth rates during run-in and the first, second and third weeks after withdrawal of prednisolone did not vary, p = 0.68.

CONCLUSION

Recovery of suppressed lower leg growth rates occurs within a week after withdrawal of exogenous glucocorticoids.

摘要

背景

全身性糖皮质激素对儿童生长的抑制作用已得到充分证实，然而，学龄儿童短期治疗停药后的生长恢复情况尚未得到评估。

目的

评估全身性糖皮质激素停药后的短期生长情况。

方法

对一项双盲小腿生长试验的数据进行事后分析，该试验比较了每晚一次服用5mg泼尼松龙与安慰剂的效果。该研究包括为期1周的导入期、治疗期、洗脱期和恢复期。在10名哮喘儿童（平均年龄11岁）中，使用骨度计测量小腿生长情况，可在停用泼尼松龙后长达3周进行研究。

结果

导入期、泼尼松龙治疗期以及停用泼尼松龙后的第一周、第二周和第三周的平均（标准误）小腿生长速率分别为0.48（0.15）、-0.27（0.20）、0.53（0.19）、0.72（0.16）和0.66（0.14）mm/周，p<0.001。导入期以及停用泼尼松龙后的第一周、第二周和第三周的平均生长速率无差异，p = 0.68。