Pellegrini A, Colombo T, Donatelli F, Lanfranchi M, Quaini E, Russo C, Vitali E
A. De Gasperis Cardiac Surgery Division, Hospital Niguarda, Ca Granda, Milan, Italy.
Eur J Cardiothorac Surg. 1992;6(6):288-96. doi: 10.1016/1010-7940(92)90144-m.
To define the role of functional tricuspid insufficiency and right ventricular (RV) failure in patients with mitral disease, the data of 121 patients with secondary tricuspid insufficiency that underwent mitral valve replacement (MVR) from January 1982 to December 1987 were analyzed. The mitral hemodynamic lesion was: stenosis in 41 patients (33.9%); insufficiency in 11 (9.1%) and mixed stenosis and insufficiency in 69 (57.0%). NYHA functional class was: II in 4 patients (3.3%), III in 78 (64.5%) and IV in 39 (32.2%). In 100 cases (group 1) with tricuspid insufficiency defined as moderate or severe, a De Vega annuloplasty was performed while in 21 (group 2) with mild tricuspid insufficiency, no tricuspid surgical procedure was performed. Hospital deaths occurred in 17 of 121 patients [14% (CL 10.8-17.0)]. There was no significant difference in hospital mortality between group 1 and group 2 (15% vs 9.5%; P = 0.75). Incremental risk factors for hospital mortality as determined by multivariate analysis, include: cardiothoracic ratio (P = 0.0016), total aortic cross-clamp time (P = 0.006), associated cardiac disease (P = 0.0209) and emergency operations (P = 0.0318). Mean follow-up of surviving patients was 50.1 +/- 28.1 months. Late deaths occurred in 16 patients [15.4% (CL 11.7-18.7)]. The actuarial survival rate was 85.6% and 73.8% at 5 and 9 years, respectively. Nine patients [8.6% (CL 5.9-11.3)] required reoperation. There was no significant difference between group 1 and group 2 in the rate of late cardiac related deaths (5.9% vs 5.3%, P = 0.66) and of tricuspid reoperations (4.7% vs 5.3%, P = 0.62).(ABSTRACT TRUNCATED AT 250 WORDS)
为明确功能性三尖瓣关闭不全及右心室(RV)衰竭在二尖瓣疾病患者中的作用,分析了1982年1月至1987年12月期间121例行二尖瓣置换术(MVR)的继发性三尖瓣关闭不全患者的数据。二尖瓣血流动力学病变情况为:41例(33.9%)为狭窄;11例(9.1%)为关闭不全;69例(57.0%)为狭窄合并关闭不全。纽约心脏协会(NYHA)心功能分级为:Ⅱ级4例(3.3%),Ⅲ级78例(64.5%),Ⅳ级39例(32.2%)。100例三尖瓣关闭不全定义为中度或重度的患者(第1组)行De Vega瓣环成形术,21例轻度三尖瓣关闭不全的患者(第2组)未行三尖瓣手术。121例患者中有17例(14%,可信区间10.8 - 17.0)院内死亡。第1组和第2组的院内死亡率无显著差异(15%对9.5%;P = 0.75)。多因素分析确定的院内死亡增加危险因素包括:心胸比率(P = 0.0016)、主动脉总阻断时间(P = 0.006)、相关心脏疾病(P = 0.0209)及急诊手术(P = 0.0318)。存活患者的平均随访时间为50.1±28.1个月。16例患者(15.4%,可信区间11.7 - 18.7)出现晚期死亡。5年和9年的精算生存率分别为85.6%和73.8%。9例患者(8.6%,可信区间5.9 - 11.3)需要再次手术。第1组和第2组在晚期心脏相关死亡发生率(5.9%对5.3%,P = 0.66)及三尖瓣再次手术率(4.7%对5.3%,P = 0.62)方面无显著差异。(摘要截选至250词)