Li Jia Ping, de Wijn Joost R, Van Blitterswijk Clemens A, de Groot Klaas
Institute for Biomedical Technology, Twente University, Prof. Bronkhorstlaan 10-D, 3723 MB Bilthoven, The Netherlands.
Biomaterials. 2006 Mar;27(8):1223-35. doi: 10.1016/j.biomaterials.2005.08.033. Epub 2005 Oct 5.
Three-dimensional (3D) fiber deposition (3DF), a rapid prototyping technology, was successfully directly applied to produce novel 3D porous Ti6Al4V scaffolds with fully interconnected porous networks and highly controllable porosity and pore size. A key feature of this technology is the 3D computer-controlled fiber depositing of Ti6Al4V slurry at room temperature to produce a scaffold, consisting of layers of directionally aligned Ti6Al4V fibers. In this study, the Ti6Al4V slurry was developed for the 3D fiber depositing process, and the parameters of 3D fiber depositing were optimized. The experimental results show how the parameters influence the structure of porous scaffold. The potential of this rapid prototyping 3DF system for fabricating 3D Ti6Al4V scaffolds with regular and reproducible architecture meeting the requirements of tissue engineering and orthopedic implants is demonstrated.
三维（3D）纤维沉积（3DF）是一种快速成型技术，已成功直接应用于制造具有完全互连的多孔网络以及高度可控的孔隙率和孔径的新型3D多孔Ti6Al4V支架。该技术的一个关键特性是在室温下对Ti6Al4V浆料进行三维计算机控制的纤维沉积以制造支架，该支架由定向排列的Ti6Al4V纤维层组成。在本研究中，开发了用于3D纤维沉积过程的Ti6Al4V浆料，并优化了3D纤维沉积的参数。实验结果表明了这些参数如何影响多孔支架的结构。证明了这种快速成型3DF系统在制造符合组织工程和骨科植入物要求的具有规则且可重复结构的3D Ti6Al4V支架方面的潜力。
