Department of Orthopedics, Jinling Hospital, The First School of Clinical Medicine, Southern Medical University, Nanjing, 210002, People's Republic of China.
Department of Orthopedics, Jinling Hospital, Nanjing Medical University, Nanjing, 210002, People's Republic of China.
Ann Biomed Eng. 2022 Aug;50(8):898-913. doi: 10.1007/s10439-022-02970-9. Epub 2022 May 7.
The reconstruction of large skeletal defects is still a tricky challenge in orthopedics. The newly formed bone tissue migrates sluggishly from the periphery to the center of the scaffold due to the restrictions of exchange of oxygen and nutrition impotent cells osteogenic differentiation. Angiogenesis plays an important role in bone reconstruction and more and more studies on angiogenesis in bone tissue engineering had been published. Promising advances of angiogenesis in bone tissue engineering by scaffold designs, angiogenic factor delivery, in vivo prevascularization and in vitro prevascularization are discussed in detail. Among all the angiogenesis mode, angiogenic factor delivery is the common methods of angiogenesis in bone tissue engineering and possible research directions in the future.
在骨科领域，重建大的骨骼缺损仍然是一个棘手的挑战。由于氧和营养物质交换受限以及细胞成骨分化能力不足，新形成的骨组织从外围缓慢迁移到支架的中心。血管生成在骨重建中起着重要作用，越来越多的关于骨组织工程中血管生成的研究已经发表。详细讨论了支架设计、血管生成因子递送、体内预血管化和体外预血管化等方法在骨组织工程中促进血管生成的有前景的进展。在所有的血管生成模式中，血管生成因子递送是骨组织工程中血管生成的常用方法，也是未来可能的研究方向。
