Boulanger Loïc, Boukerrou Malik, Lambaudie Eric, Defossez André, Cosson Michel
Department of Gynecologic Surgery, Hôpital Jeanne de Flandre, Centre Hospitalier Régional Universitaire de Lille, Avenue Eugène Avinée, 59037 Lille Cedex, France.
Eur J Obstet Gynecol Reprod Biol. 2006 Mar 1;125(1):103-8. doi: 10.1016/j.ejogrb.2005.07.029. Epub 2005 Sep 19.
To evaluate the tissue integration of and tolerance to five different mesh types used in genital prolapse surgery to provide mechanical support.
We placed five different meshes (Vicryl, Vypro, Prolene, Prolene soft, and Mersuture) on the peritoneums of 12 pigs. After 10 weeks, we used light microscopy to analyze the tissue integration of and tolerance to these meshes. We looked for inflammation, vascularization, fibroblasts, collagen fibers and the organization of connective tissue.
The absorbable prostheses made of polyglactin 910 (Vicryl) and the non-absorbable prostheses made of polypropylene (Prolene and Prolene soft) induced the least severe inflammatory reactions. Tissue integration was best with the polypropylene meshes, which allowed the development of a well-organized, fibrous, mature, connective tissue.
The tissue response to prosthetic meshes depends on the material used and its structure. This work highlights the feasibility of carrying out experimental studies to test the tolerance to and integration of biomaterials used in gynecology. Such studies need to be carried out whenever new prostheses become available to validate their use in common practice.
评估用于生殖器脱垂手术以提供机械支撑的五种不同网片类型的组织整合情况及耐受性。
我们将五种不同的网片（薇乔、维普乐、聚丙烯、聚丙烯柔软型和爱惜康缝线）放置在12头猪的腹膜上。10周后，我们使用光学显微镜分析这些网片的组织整合情况及耐受性。我们观察炎症、血管形成、成纤维细胞、胶原纤维以及结缔组织的结构。
由聚乙交酯910制成的可吸收假体（薇乔）和由聚丙烯制成的不可吸收假体（聚丙烯和聚丙烯柔软型）引起的炎症反应最轻微。聚丙烯网片的组织整合效果最佳，能形成组织良好、纤维性、成熟的结缔组织。
对假体网片的组织反应取决于所用材料及其结构。这项工作凸显了开展实验研究以测试妇科所用生物材料的耐受性和整合情况的可行性。每当有新的假体可用时，都需要进行此类研究以验证其在常规实践中的应用。
